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Protein Overview: URA8

General Information:
Name(s) found: URA8 / YJR103W [SGD]
Description(s) found:
Found 20 descriptions.
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  • Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 564 amino acids

    Gene Ontology:
    Cellular Component: cytosol [TASLink to PubMed article]
    Biological Process: CTP biosynthetic process [IDALink to PubMed article]
    phospholipid biosynthetic process [TASLink to PubMed article]
    pyrimidine base biosynthetic process [IMPLink to PubMed article][TASLink to PubMed article]
    Molecular Function: CTP synthase activity [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKYVVVSGGV ISGIGKGVLA SSTGMLLKTL GLKVTSIKID PYMNIDAGTM SPLEHGECFV  60
   61 LDDGGETDLD LGNYERYLGI TLSRDHNITT GKIYSHVISR ERRGDYLGKT VQIVPHLTNA 120
  121 IQDWIQRVSK IPVDDTGLEP DVCIIELGGT VGDIESAPFV EALRQFQFEV GRENFALIHV 180
  181 SLVPVIHGEQ KTKPTQAAIK DLRSLGLIPD MIACRCSEEL NRSTIDKIAM FCHVGPEQVV 240
  241 NVHDVNSTYH VPLLLLKQHM IDYLHSRLKL GEVPLTLEDK ERGSQLLTNW ENMTKNLDDS 300
  301 DDVVKIALVG KYTNLKDSYL SVTKSLEHAS MKCRRQLEIL WVEASNLEPE TQEVDKNKFH 360
  361 DSWNKLSSAD GILVPGGFGT RGIEGMILAA KWARESGVPF LGVCLGLQVA AIEFARNVIG 420
  421 RPNSSSTEFL DETLLAPEDQ VVIYMPEIDK EHMGGTMRLG LRPTIFQPNS EWSNIRKLYG 480
  481 EVNEVHERHR HRYEINPKIV NDMESRGFIF VGKDETGQRC EIFELKGHPY YVGTQYHPEY 540
  541 TSKVLEPSRP FWGLVAAAPA HLVK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ACF2 DTR1 LSB1 SBA1 SRO77 URA8 YGL140C YOR262W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data URA8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..208] ORFEUS 7.75 Nitrogenase iron protein
    2 View Details [209..564] PSI-BLAST 63.522879 Carbamoyl phosphate synthetase, small subunit N-terminal domain; Carbamoyl phosphate synthetase, small subunit C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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