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Protein Overview: HUL4

General Information:
Name(s) found: HUL4 / YJR036C [SGD]
Description(s) found:
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  • gi|6322497|ref|NP_012570.1| Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability; Hul4p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1197064|gb|AAA88738.1| ORF; putative [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1176337|sp|P40985.2|HUL4_YEAST RecName: Full=Probable E3 ubiquitin-protein ligase HUL4; AltName: Full=HECT ubiquitin ligase 4 [NCBI NR]
  • pir||S57055 probable membrane protein YJR036c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1015685|emb|CAA89563.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Probable E3 ubiquitin-protein ligase HUL4 OS=Saccharomyces cerevisiae GN=HUL4 PE=1 SV=2 [Swiss-Prot]
  • HUL4 Hect domain E3 ubiquitin-protein ligase [mips]
  • Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability [SGD]
  • HUL4, Chr X from 500405-503083, reverse complement [yeast_orfs2]
  • Chr X from 500405-503083, reverse complement [yeastorf3.fasta]
  • Chr X from 500406-503084, reverse complement [yeastorf4.fasta]
  • Chr X from 503085-500407, reverse complement [yeastorf5.fasta]
  • (P40985) Probable ubiquitin--protein ligase HUL4 (EC 6.3.2.-) [4932.FASTACCERV.txt]
  • HUL4 SGDID:S0003797, Chr X from 503305-500627, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Hul4p [Saccharomyces cerevisiae]gi|1015685|emb|CAA89563.1| unnamed protein product [Saccharomyces cerevisiae]gi|1077879|pir||S57055 probable membrane protein YJR036c - yeast (Saccharomyces cerevisiae)gi|1197064|gb|AAA88738.1| ORF; putativegi|1176337|s [nrdb_11152004_Chlamydomonas]
  • HUL4 SGDID:S000003797, Chr X from 503305-500627, reverse complement, Verified ORF, "Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • HUL4 SGDID:S000003797, Chr X from 503384-500706, reverse complement, Verified ORF, "Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability" [yeast-contam.fasta]
  • HUL4 SGDID:S000003797, Chr X from 503383-500705, reverse complement, Verified ORF, "Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability" [yeast-200209-contam.fasta]
  • Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability; Hul4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Probable ubiquitin-protein ligase HUL4 (HECT ubiquitin ligase 4) [nr-271106-contam.fasta]
  • ORF; putative [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Probable E3 ubiquitin-protein ligase HUL4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HUL4 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • HUL4 SGDID:S000003797, Chr X from 503391-500713, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability" [yeast-030211-contam.fasta]
  • HUL4 SGDID:S000003797, Chr X from 503391-500713, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex" [20141208_orf_trans.fasta]
  • YJR036C SGDID:S000003797, Chr X from 503391-500713, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 892 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: protein polyubiquitination [TASLink to PubMed article]
    protein monoubiquitination [TASLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSLFDKLNA KKDGRDGSVS KELLSHSVAH TKNRLPKSGR RTSERSLAAS VKDGSCSNSK  60
   61 SNKRNSSASV SGEEDKSCLI SLNCLCCGVP LRFPASITKF RCSACQVTVI VKEPEINSNL 120
  121 ESSTHISCTL EGLQMVVRRC HDDLQRLKKT GILDKERKGL IFQPVITYLL DRFHDVSILN 180
  181 RSFLVHDGGK NIKMLNYEVL QRFYSILSNL PTRKPYYSML CCCNDLLKRI TINKGENLQI 240
  241 LQYRWLLIIL NIPTIRTCLI RDRKSKNVFE TQQIRAVSYE LAKRCIGYLS NLSTKTSQQL 300
  301 IQSLRRTPTD NFSYQVEILN LYINFQFSRL LSNELSNRTA KNNVKPEDEM RSRLRRHHTT 360
  361 GHEFLSTRPI SAQSNDKQGS GFTHPVNNKM KFKFFQYEED WHIHSAAKLT FIYYVANTRR 420
  421 NGRGALSIQS FYNITLDFID YKQDFDHWRG VAQKTKMNQL IEEWGNSTTK KCFSFCKYPF 480
  481 ILSLGIKISI MEYEIRRIME HEAEQAFLIS LDKGKSVDVY FKIKVRRDVI SHDSLRCIKE 540
  541 HQGDLLKSLR IEFVNEPGID AGGLRKEWFF LLTKSLFNPM NGLFIYIKES SRSWFAIDPP 600
  601 NFDKSKGKNS QLELYYLFGV VMGLAIFNST ILDLQFPKAL YKKLCSEPLS FEDYSELFPE 660
  661 TSRNLIKMLN YTEDNFEDVF SLTFETTYRN NNWILNDSKS SKEYVTVELC ENGRNVPITQ 720
  721 SNKHEFVMKW VEFYLEKSIE PQYNKFVSGF KRVFAECNSI KLFNSEELER LVCGDEEQTK 780
  781 FDFKSLRSVT KYVGGFSDDS RAVCWFWEII ESWDYPLQKK LLQFVTASDR IPATGISTIP 840
  841 FKISLLGSHD SDDLPLAHTC FNEICLWNYS SKKKLELKLL WAINESEGYG FR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) HUL4 MCK1 PRD1 YGR012W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SWI5 HUL4 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..448] deduced N/A No confident structure predictions are available.
    2 View Details [449..559] PSI-BLAST 710.0103 Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
    3 View Details [560..662]
    [731..774]    		 PSI-BLAST 710.0103 Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
    4 View Details [663..730]
    [775..892]    		 PSI-BLAST 710.0103 Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
    5 View Details [509..892] PSI-BLAST 122.0 Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.14616396317218 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  6.99796579811325 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.03005793772151 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  4.50502148129705 bayes_pls_golite062009
  • sodium channel inhibitor activity
    		•  3.64966529121446 bayes_pls_golite062009
  • proline-rich region binding
    		•  3.26053533977534 bayes_pls_golite062009
  • phosphothreonine binding
    		•  2.3451206920409 bayes_pls_golite062009
  • phosphoserine binding
    		•  2.3451206920409 bayes_pls_golite062009
  • binding
    		•  2.32045312021486 bayes_pls_golite062009
  • ion channel inhibitor activity
    		•  2.14402963004533 bayes_pls_golite062009
  • channel inhibitor activity
    		•  2.14402963004533 bayes_pls_golite062009
  • RNA polymerase binding
    		•  1.8762146737407 bayes_pls_golite062009
  • ligase activity
    		•  1.85936914071714 bayes_pls_golite062009
  • protein binding
    		•  1.29390544644063 bayes_pls_golite062009
  • sodium channel regulator activity
    		•  1.19047973745862 bayes_pls_golite062009
  • catalytic activity
    		•  1.15152367676155 bayes_pls_golite062009
  • transcription factor binding
    		•  0.585725073778084 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.509776214744915 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.376852535152545 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  0.373649200425601 bayes_pls_golite062009
  • DNA binding
    		•  0.187697131456126 bayes_pls_golite062009
  • channel regulator activity
    		•  0.072778668515899 bayes_pls_golite062009
    		• 0.051942165438844 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.72

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle