Protein Overview: TES1

General Information:
Name(s) found:	TES1 / YJR019C [SGD]
Description(s) found: Found 32 descriptions. SHOW ALL	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids [SGD]
Organism:	Saccharomyces cerevisiae
Length:	349 amino acids
Gene Ontology:
Cellular Component:	peroxisome [IDA] mitochondrion [IDA ]
Biological Process:	fatty acid oxidation [IEP][IMP]
Molecular Function:	acyl-CoA thioesterase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSASKMAMSN LEKILELVPL SPTSFVTKYL PAAPVGSKGT FGGTLVSQSL LASLHTVPLN  60
   61 FFPTSLHSYF IKGGDPRTKI TYHVQNLRNG RNFIHKQVSA YQHDKLIFTS MILFAVQRSK 120
  121 EHDSLQHWET IPGLQGKQPD PHRYEEATSL FQKEVLDPQK LSRYASLSDR FQDATSMSKY 180
  181 VDAFQYGVME YQFPKDMFYS ARHTDELDYF VKVRPPITTV EHAGDESSLH KHHPYRIPKS 240
  241 ITPENDARYN YVAFAYLSDS YLLLTIPYFH NLPLYCHSFS VSLDHTIYFH QLPHVNNWIY 300
  301 LKISNPRSHW DKHLVQGKYF DTQSGRIMAS VSQEGYVVYG SERDIRAKF

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		DCI1 FOX2 TES1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC7	TES1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..349]	PSI-BLAST	195.29073	Thioesterase II (TesB)
2	View Details	[131..349]	FFAS03	7.51	Thioesterase II (TesB)

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
acyl-CoA thioesterase activity	2.60197973503923	bayes_pls_golite062009
CoA hydrolase activity	2.3187640589669	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.14159464719086	bayes_pls_golite062009
thiolester hydrolase activity	1.14125301545576	bayes_pls_golite062009
catalytic activity	0.74605540351792	bayes_pls_golite062009
binding	0.358549779743531	bayes_pls_golite062009
hydrolase activity	0.093543122203219	bayes_pls_golite062009

Term	Confidence	Notes
acyl-CoA thioesterase activity	2.09910961810984	bayes_pls_golite062009
CoA hydrolase activity	1.78895388806948	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.07218515999697	bayes_pls_golite062009
catalytic activity	0.713153177522975	bayes_pls_golite062009
thiolester hydrolase activity	0.68445696143302	bayes_pls_golite062009
binding	0.425102971682545	bayes_pls_golite062009
hydrolase activity	0.0388706889258174	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.85

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2