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Catalysis of the reaction: (S)-methylmalonyl-CoA + H2O = methylmalonate + CoA. Catalysis of the reaction: succinyl-CoA + H2O = CoA + succinate. Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA. Catalysis of the reaction: phenylglyoxylyl-CoA + H2O = phenylglyoxylate + CoA. Catalysis of the reaction: acyl-CoA + H2O = corresponding fatty acid + CoA. Catalysis of the reaction: deoxycholoyl-CoA + H2O = CoA + deoxycholate. Catalysis of the hydrolysis of any ester bond. Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA. Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. Catalysis of the reaction: acetoacetyl-CoA + H2O = CoA + acetoacetate. Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate. Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. Catalysis of the reaction: formyl-CoA + H2O = CoA + formate. Catalysis of the reaction: acetyl-CoA + H2O = CoA + acetate. Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = CoA + 3-hydroxy-3-methylglutarate. Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: CoA hydrolase activity
Acc: GO:0016289
Aspect: Molecular Function
Desc: Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group.
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 117 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016289 - CoA hydrolase activity (interactive image map)

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