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Protein Overview: SSY5

General Information:
Name(s) found: SSY5 / YJL156C [SGD]
Description(s) found:
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  • gi|6322305|ref|NP_012379.1| Probable serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that regulate expression of amino acid permeas [NCBI NR]
  • gi|1353024|sp|P47002.1|SSY5_YEAST RecName: Full=Protein SSY5 [NCBI NR]
  • pir||S56939 probable membrane protein YJL156c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1015577|emb|CAA89451.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Protein SSY5 OS=Saccharomyces cerevisiae GN=SSY5 PE=2 SV=1 [Swiss-Prot]
  • SSY5 Part of an extracellular amino acid sensor [mips]
  • Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p [SGD]
  • SSY5, Chr X from 126587-128650, reverse complement [yeast_orfs2]
  • Chr X from 126587-128650, reverse complement [yeastorf3.fasta]
  • Chr X from 128650-126587, reverse complement [yeastorf5.fasta]
  • (P47002) SSY5 protein [4932.FASTACCERV.txt]
  • SSY5 SGDID:S0003692, Chr X from 128870-126807, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes [Saccharomyces cerev [nrdb_11152004_Chlamydomonas]
  • SSY5 SGDID:S000003692, Chr X from 128870-126807, reverse complement, Verified ORF, "Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • SSY5 SGDID:S000003692, Chr X from 128949-126886, reverse complement, Verified ORF, "Probable serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellula [yeast-contam.fasta]
  • Probable serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that regulate expression of amino acid permease genes; Ssy5p [Saccharomyce [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein SSY5 [nr-271106-contam.fasta]
  • SSY5 SGDID:S000003692, Chr X from 128949-126886, reverse complement, Verified ORF, "Probable serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that regulate expression of amino acid permease genes" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 687 amino acids

    Gene Ontology:
    Cellular Component: extrinsic to plasma membrane [IDALink to PubMed article]
    Biological Process: response to amino acid stimulus [IGILink to PubMed article][IMPLink to PubMed article]
    protein processing [IMPLink to PubMed article]
    Molecular Function: serine-type endopeptidase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRFFGLNKK KNEEKENTDL PADNEQNAAE TSSSNVSGNE ERIDPNSHDT NPENANNDDA  60
   61 STTFGSSIQS SSIFSRGRMT YGTGASSSMA TSEMRSHSSG HSGSKNSKNL QGFKDVGKPL 120
  121 RAVSFLSPVK EEESQDTQNT LDVSSSTSST LATSENAREN SFTSRRSITL EYIHKSLSEL 180
  181 EENLVDIMDD IHQDVISISK AVIEAIEYFK EFLPTTRDRI PYRISLEKSS SLRKINKIVL 240
  241 HFLDNLLVSD AFSNSRSILL RRFYFFLKKL NLITDDDLIS ESGVLPCLSV FCIGSHCNLP 300
  301 SMDKLGMILD ELTKMDSSII SDQEGAFIAP ILRGITPKSS ILTIMFGLPN LQHEHYEMIK 360
  361 VLYSLFPDVH MYCVKDYIKK AASAVGSIPS HTAATIDTIA PTKFQFSPPY AVSENPLELP 420
  421 ISMSLSTETS AKITGTLGGY LFPQTGSDKK FSQFASCSFA ITCAHVVLSE KQDYPNVMVP 480
  481 SNVLQTSYKK VLTKESDRYP DGSVEKTAFL EEVQRIDQNL NWQKSNKFGQ VVWGERAIVD 540
  541 HRLSDFAIIK VNSSFKCQNT LGNGLKSFPD PTLRFQNLHV KRKIFKMKPG MKVFKIGAST 600
  601 GYTSGELNST KLVYWADGKL QSSEFVVASP TPLFASAGDS GAWILTKLED RLGLGLVGML 660
  661 HSYDGEQRQF GLFTPIGDIL ERLHDCN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CLU1 CYC8 ECM10 SPH1 SSY5 TUP1
    View Details Qiu et al. (2008) PTR3 SSY5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SWI5 SSY5 1 Unpublished Fields Lab Data
    View Screen SPT21 SSY5 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SSY5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..687] deduced N/A No confident structure predictions are available.
    2 View Details [118..392] FFAS03 3.74 CYTOHESIN-1/B2-1 SEC7 DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
    3 View Details [393..567] deduced N/A No confident structure predictions are available.
    4 View Details [568..687] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  0.854302719902887 bayes_pls_golite062009
  • protein binding
    		•  0.434681706304734 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.181787767073972 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle