Protein Overview: IKS1

General Information:
Name(s) found:	IKS1 / YJL057C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322404\|ref\|NP_012478.1\| Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p; Iks1p [Saccharomy [NCBI NR] gi\|1346384\|sp\|P47042.1\|IKS1_YEAST RecName: Full=Probable serine/threonine-protein kinase IKS1; AltName: Full=IRA1 kinase suppressor 1 [NCBI NR] pir\|\|S56829 probable membrane protein YJL057c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1008199\|emb\|CAA89348.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Probable serine/threonine-protein kinase YJL057C OS=Saccharomyces cerevisiae GN=YJL057C PE=1 SV=1 [Swiss-Prot] Probable serine/threonine-protein kinase IKS1 OS=Saccharomyces cerevisiae GN=IKS1 PE=1 SV=1 [Swiss-Prot] IKS1 Putative serine/threonine kinase [mips] Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p [SGD] IKS1, Chr X from 327814-329817, reverse complement [yeast_orfs2] Chr X from 327814-329817, reverse complement [yeastorf3.fasta] Chr X from 329817-327814, reverse complement [yeastorf5.fasta] (P47042) Probable serine/threonine-protein kinase YJL057C (EC 2.7.1.-) [4932.FASTACCERV.txt] YJL057C SGDID:S0003593, Chr X from 330037-328034, reverse complement, Uncharacterized ORF [yeastflysequest.fasta] Yjl057cp [Saccharomyces cerevisiae]gi\|1008199\|emb\|CAA89348.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1078231\|pir\|\|S56829 probable membrane protein YJL057c - yeast (Saccharomyces cerevisiae)gi\|1346384\|sp\|P47042\|KJF7_YEAST Probable serine/t [nrdb_11152004_Chlamydomonas] (P47042) Probable serine/threonine-protein kinase YJL057C (EC 2.7.1.37) [cerv4932.FASTAC] YJL057C SGDID:S000003593, Chr X from 330037-328034, reverse complement, Uncharacterized ORF, "probable serine/threonine kinase" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] IKS1 SGDID:S000003593, Chr X from 330116-328113, reverse complement, Uncharacterized ORF, "Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; in [yeast-contam.fasta] IKS1 SGDID:S000003593, Chr X from 330116-328113, reverse complement, Verified ORF, "Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] IKS1 SGDID:S000003593, Chr X from 330115-328112, reverse complement, Verified ORF, "Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts [yeast-200209-contam.fasta] Probable serine/threonine-protein kinase YJL057C [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p; Iks1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] IKS1 SGDID:S000003593, Chr X from 330115-328112, reverse complement, Verified ORF, "Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p" [yeast-bovrabprots.fasta] IKS1 SGDID:S000003593, Chr X from 330116-328113, reverse complement, Uncharacterized ORF, "Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p" [yeast-contam_custom.fasta] [chemostatdb.fasta] Probable serine/threonine-protein kinase IKS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IKS1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] IKS1 SGDID:S000003593, Chr X from 330121-328118, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p" [yeast-030211-contam.fasta] IKS1 SGDID:S000003593, Chr X from 330121-328118, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p" [20141208_orf_trans.fasta] YJL057C SGDID:S000003593, Chr X from 330121-328118, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	667 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLVPYEEGS LILDDPNSKS VVVVNPTSGT LSFFQQDNSN NDSELNEDQT ASLSALDFPS  60
   61 GIHQYKSPIA SYVCPQCGTE INPDIINRRQ LHRRASAGVE SESSRLSIPE NTVPLGFEFA 120
  121 NSSFSRRYFQ SLERNHRHYA LQNDSNNKQG QFSKNKYFIP DDLFIPGYFR KFFKILSLLG 180
  181 NGARGSVYKV VHTIGNTELG VFALKKIPIG NDMEWFNKCI REVKALSSLT HKSANLITYN 240
  241 HVWLEMDSSV GFVRSIDGSQ SDSQEEVPCI FILQQYCSGG NLEDCILRKV FNRFSDTESP 300
  301 EERKKKFRTR KKNHGKSGEV GLSTEQLVSI IRDIARGLHE LHSIGLIHRD LKPSNCLLLT 360
  361 PFKSDNENDN VYDREHNSDE FFPSIVIGDL GESQLEGESR LGTGCTGTLE FTAPDLIIQG 420
  421 RPVSSSTLPS RSSHTYNEYT FASDMYSLGM ICYFIVFGEL PFEPQLDIVD LKVRIKNFRF 480
  481 DTEGMIEKHQ AMKLKPIDRR IFHLMDALLQ PNNDARPTAK TVEETLDEML INSKPGKKFW 540
  541 KENVDSTLNF STISEVNENT NSFTDDYIDG DNVTLSLPAP EENLSTVSTQ NLQKYSALNR 600
  601 TIQVCYKLVS MILTIIIFKC TKTGSWLSYM SLILLGMVFK SPADERGKHA RALVLLAFIA 660
  661 ACKKYIY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SST2	IKS1	2	Unpublished Fields Lab Data
View Screen	YIF1	IKS1	2	Unpublished Fields Lab Data
View Screen	PHS1	IKS1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	IKS1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..140]	deduced	N/A	No confident structure predictions are available.
2	View Details	[141..279]	PSI-BLAST	148.38764	Calmodulin-dependent protein kinase
3	View Details	[280..570]	PSI-BLAST	148.38764	Calmodulin-dependent protein kinase
4	View Details	[571..667]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.73

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2