YRC Public Data Repository - Protein Structure Prediction

Protein:	IKS1
Organism:	Saccharomyces cerevisiae
Length:	667 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IKS1.

Description	E-value	Query Range	Subject Range
IKS1 - Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants ar... IKS1_YEAST - Probable serine/threonine-protein kinase IKS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...	0.0	[1..667]	[1..667]
gi\|4589580 - gi\|4589580\|dbj\|BAA76812.1\| KIAA0968 protein [Homo sapiens]	0.0	[122..642]	[14..431]
gi\|15289758 - gi\|15289758\|dbj\|BAB63463.1\| calcium dependent protein kinase [Solanum tuberosum]	0.0	[68..645]	[18..442]
CDPK2_ARATH - Calcium-dependent protein kinase 2 OS=Arabidopsis thaliana GN=CPK2 PE=1 SV=1	0.0	[37..644]	[49..513]
gi\|16215471 - gi\|16215471\|emb\|CAC82999.1\| calcium-dependent protein kinase 3 [Nicotiana tabacum]	0.0	[68..645]	[18..442]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[49..644]	[17..480]
gi\|117616246 - gi\|117616246\|gb\|ABK42141.1\| calmodulin-dependent protein kinase II alpha [synthetic construct] KCC2A_RAT - Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Rattus norvegicus GN=Camk2a PE=... KCC2A_MOUSE - Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Mus musculus GN=Camk2a PE=1 SV=... gi\|115495299, gi... - gi\|76623452\|ref\|XP_877000.1\| PREDICTED: similar to Calcium/calmodulin-dependent protein kinase type ...	0.0	[168..642]	[8..382]
gi\|12849628, gi\|... - gi\|18158420\|ref\|NP_076302.1\| calcium/calmodulin-dependent protein kinase II, delta isoform 3 [Mus mu... gi\|146231868 - gi\|146231868\|gb\|ABQ13009.1\| calcium/calmodulin-dependent protein kinase II delta [Bos taurus] gi\|26667189, gi\|... - gi\|26667189\|ref\|NP_742126.1\| calcium/calmodulin-dependent protein kinase II delta isoform 2 [Homo sa... gi\|109075450 - gi\|109075450\|ref\|XP_001096678.1\| PREDICTED: similar to calcium/calmodulin-dependent protein kinase I... gi\|114595764 - gi\|114595764\|ref\|XP_001146325.1\| PREDICTED: hypothetical protein isoform 4 [Pan troglodytes]	0.0	[168..642]	[9..382]
KCC2D_PIG - Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Sus scrofa GN=CAMK2D PE=2 SV=1 tr\|M3WNF0\|M3WNF0... - Calcium/calmodulin dependent protein kinase II delta OS=Felis catus GN=CAMK2D PE=3 SV=1	0.0	[168..642]	[9..382]
gi\|4063713 - gi\|4063713\|gb\|AAC98390.1\| calcium/calmodulin-dependent kinase II alpha protein [Gallus gallus]	0.0	[168..642]	[8..382]

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Predicted Domain #1

Region A:
Residues: [1-140]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLVPYEEGS LILDDPNSKS VVVVNPTSGT LSFFQQDNSN NDSELNEDQT ASLSALDFPS  60
   61 GIHQYKSPIA SYVCPQCGTE INPDIINRRQ LHRRASAGVE SESSRLSIPE NTVPLGFEFA 120
  121 NSSFSRRYFQ SLERNHRHYA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [141-279]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQNDSNNKQG QFSKNKYFIP DDLFIPGYFR KFFKILSLLG NGARGSVYKV VHTIGNTELG  60
   61 VFALKKIPIG NDMEWFNKCI REVKALSSLT HKSANLITYN HVWLEMDSSV GFVRSIDGSQ 120
  121 SDSQEEVPCI FILQQYCSG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	148.38764
Match:	1a06__
Description:	Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [280-570]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNLEDCILRK VFNRFSDTES PEERKKKFRT RKKNHGKSGE VGLSTEQLVS IIRDIARGLH  60
   61 ELHSIGLIHR DLKPSNCLLL TPFKSDNEND NVYDREHNSD EFFPSIVIGD LGESQLEGES 120
  121 RLGTGCTGTL EFTAPDLIIQ GRPVSSSTLP SRSSHTYNEY TFASDMYSLG MICYFIVFGE 180
  181 LPFEPQLDIV DLKVRIKNFR FDTEGMIEKH QAMKLKPIDR RIFHLMDALL QPNNDARPTA 240
  241 KTVEETLDEM LINSKPGKKF WKENVDSTLN FSTISEVNEN TNSFTDDYID G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	148.38764
Match:	1a06__
Description:	Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [571-667]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNVTLSLPAP EENLSTVSTQ NLQKYSALNR TIQVCYKLVS MILTIIIFKC TKTGSWLSYM  60
   61 SLILLGMVFK SPADERGKHA RALVLLAFIA ACKKYIY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits