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View Structure Prediction Details

Protein: IKS1
Organism: Saccharomyces cerevisiae
Length: 667 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IKS1.

Description E-value Query
Range
Subject
Range
IKS1 - Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants ar...
IKS1_YEAST - Probable serine/threonine-protein kinase IKS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...
0.0 [1..667] [1..667]
gi|4589580 - gi|4589580|dbj|BAA76812.1| KIAA0968 protein [Homo sapiens]
0.0 [122..642] [14..431]
gi|15289758 - gi|15289758|dbj|BAB63463.1| calcium dependent protein kinase [Solanum tuberosum]
0.0 [68..645] [18..442]
CDPK2_ARATH - Calcium-dependent protein kinase 2 OS=Arabidopsis thaliana GN=CPK2 PE=1 SV=1
0.0 [37..644] [49..513]
gi|16215471 - gi|16215471|emb|CAC82999.1| calcium-dependent protein kinase 3 [Nicotiana tabacum]
0.0 [68..645] [18..442]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [49..644] [17..480]
gi|117616246 - gi|117616246|gb|ABK42141.1| calmodulin-dependent protein kinase II alpha [synthetic construct]
KCC2A_RAT - Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Rattus norvegicus GN=Camk2a PE=...
KCC2A_MOUSE - Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Mus musculus GN=Camk2a PE=1 SV=...
gi|115495299, gi... - gi|76623452|ref|XP_877000.1| PREDICTED: similar to Calcium/calmodulin-dependent protein kinase type ...
0.0 [168..642] [8..382]
gi|12849628, gi|... - gi|18158420|ref|NP_076302.1| calcium/calmodulin-dependent protein kinase II, delta isoform 3 [Mus mu...
gi|146231868 - gi|146231868|gb|ABQ13009.1| calcium/calmodulin-dependent protein kinase II delta [Bos taurus]
gi|26667189, gi|... - gi|26667189|ref|NP_742126.1| calcium/calmodulin-dependent protein kinase II delta isoform 2 [Homo sa...
gi|109075450 - gi|109075450|ref|XP_001096678.1| PREDICTED: similar to calcium/calmodulin-dependent protein kinase I...
gi|114595764 - gi|114595764|ref|XP_001146325.1| PREDICTED: hypothetical protein isoform 4 [Pan troglodytes]
0.0 [168..642] [9..382]
KCC2D_PIG - Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Sus scrofa GN=CAMK2D PE=2 SV=1
tr|M3WNF0|M3WNF0... - Calcium/calmodulin dependent protein kinase II delta OS=Felis catus GN=CAMK2D PE=3 SV=1
0.0 [168..642] [9..382]
gi|4063713 - gi|4063713|gb|AAC98390.1| calcium/calmodulin-dependent kinase II alpha protein [Gallus gallus]
0.0 [168..642] [8..382]

Back

Predicted Domain #1
Region A:
Residues: [1-140]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLVPYEEGS LILDDPNSKS VVVVNPTSGT LSFFQQDNSN NDSELNEDQT ASLSALDFPS  60
   61 GIHQYKSPIA SYVCPQCGTE INPDIINRRQ LHRRASAGVE SESSRLSIPE NTVPLGFEFA 120
  121 NSSFSRRYFQ SLERNHRHYA 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.388 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.386 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.383 a.26.1 4-helical cytokines
View Download 0.364 a.1.1 Globin-like
View Download 0.351 a.1.1 Globin-like
View Download 0.344 c.55.3 Ribonuclease H-like
View Download 0.325 a.22.1 Histone-fold
View Download 0.324 a.24.4 Hemerythrin
View Download 0.319 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.246 d.58.16 Poly(A) polymerase, C-terminal domain
View Download 0.226 d.74.5 Hypothetical protein Yml108w
View Download 0.213 a.39.3 Cloroperoxidase
View Download 0.209 a.7.7 BAG domain
View Download 0.206 b.88.1 Mss4-like

Predicted Domain #2
Region A:
Residues: [141-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQNDSNNKQG QFSKNKYFIP DDLFIPGYFR KFFKILSLLG NGARGSVYKV VHTIGNTELG  60
   61 VFALKKIPIG NDMEWFNKCI REVKALSSLT HKSANLITYN HVWLEMDSSV GFVRSIDGSQ 120
  121 SDSQEEVPCI FILQQYCSG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 148.38764
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [280-570]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNLEDCILRK VFNRFSDTES PEERKKKFRT RKKNHGKSGE VGLSTEQLVS IIRDIARGLH  60
   61 ELHSIGLIHR DLKPSNCLLL TPFKSDNEND NVYDREHNSD EFFPSIVIGD LGESQLEGES 120
  121 RLGTGCTGTL EFTAPDLIIQ GRPVSSSTLP SRSSHTYNEY TFASDMYSLG MICYFIVFGE 180
  181 LPFEPQLDIV DLKVRIKNFR FDTEGMIEKH QAMKLKPIDR RIFHLMDALL QPNNDARPTA 240
  241 KTVEETLDEM LINSKPGKKF WKENVDSTLN FSTISEVNEN TNSFTDDYID G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 148.38764
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [571-667]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNVTLSLPAP EENLSTVSTQ NLQKYSALNR TIQVCYKLVS MILTIIIFKC TKTGSWLSYM  60
   61 SLILLGMVFK SPADERGKHA RALVLLAFIA ACKKYIY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.786 a.46.1 Methionine synthase domain
View Download 0.769 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.734 a.24.4 Hemerythrin
View Download 0.721 a.24.17 Group V grass pollen allergen
View Download 0.696 a.7.6 Ribosomal protein S20
View Download 0.547 d.8.1 Urease, gamma-subunit
View Download 0.544 a.118.11 Cytochrome c oxidase subunit E
View Download 0.539 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.538 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.537 e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View Download 0.529 a.165.1 Myosin phosphatase inhibitor 17kDa protein, CPI-17
View Download 0.521 a.1.1 Globin-like
View Download 0.515 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.513 a.24.9 alpha-catenin/vinculin
View Download 0.511 a.3.1 Cytochrome c
View Download 0.498 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.493 a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.477 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.427 d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.417 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.416 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.401 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.393 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.388 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.382 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.367 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.366 a.61.1 Retroviral matrix proteins
View Download 0.364 a.29.4 RecG, N-terminal domain
View Download 0.363 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.360 a.24.11 Bacterial GAP domain
View Download 0.339 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.331 a.29.2 Bromodomain
View Download 0.320 a.4.5 "Winged helix" DNA-binding domain
View Download 0.319 d.109.1 Actin depolymerizing proteins
View Download 0.316 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.314 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.310 d.56.1 GroEL-intermediate domain like
View Download 0.310 a.26.1 4-helical cytokines
View Download 0.307 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.306 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.306 f.17.1 F1F0 ATP synthase subunit C
View Download 0.306 a.24.3 Cytochromes
View Download 0.304 b.82.4 Regulatory protein AraC
View Download 0.298 a.133.1 Phospholipase A2, PLA2
View Download 0.292 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.283 b.40.4 Nucleic acid-binding proteins
View Download 0.281 a.24.3 Cytochromes
View Download 0.276 a.3.1 Cytochrome c
View Download 0.274 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.274 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.271 a.25.1 Ferritin-like
View Download 0.265 a.77.1 DEATH domain
View Download 0.265 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.263 a.51.1 Cytochrome c oxidase subunit h
View Download 0.262 a.112.1 Description not found.
View Download 0.262 a.11.2 Second domain of FERM
View Download 0.261 a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.258 a.39.1 EF-hand
View Download 0.255 d.56.1 GroEL-intermediate domain like
View Download 0.255 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.252 a.61.1 Retroviral matrix proteins
View Download 0.249 a.47.2 t-snare proteins
View Download 0.244 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.243 a.4.5 "Winged helix" DNA-binding domain
View Download 0.238 a.130.1 Chorismate mutase II
View Download 0.238 f.14.1 Voltage-gated potassium channels
View Download 0.235 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.233 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.232 a.1.1 Globin-like
View Download 0.232 a.4.1 Homeodomain-like
View Download 0.232 a.24.17 Group V grass pollen allergen
View Download 0.229 a.4.1 Homeodomain-like
View Download 0.229 a.185.1 Gametocyte protein Pfg27
View Download 0.224 d.58.42 N-utilization substance G protein NusG, N-terminal domain
View Download 0.224 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.220 a.61.1 Retroviral matrix proteins
View Download 0.218 a.133.1 Phospholipase A2, PLA2
View Download 0.217 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.212 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.207 a.19.1 Fertilization protein
View Download 0.205 a.1.1 Globin-like
View Download 0.205 d.79.1 YjgF-like
View Download 0.204 a.4.1 Homeodomain-like
View Download 0.202 a.156.1 S13-like H2TH domain
View Download 0.200 a.60.9 lambda integrase-like, N-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle