Protein Overview: CTM1

General Information:
Name(s) found:	CTM1 / YHR109W [SGD]
Description(s) found: Found 21 descriptions. SHOW ALL	Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth [SGD]
Organism:	Saccharomyces cerevisiae
Length:	585 amino acids
Gene Ontology:
Cellular Component:	cytosol [IDA]
Biological Process:	protein modification process [IDA]
Molecular Function:	[cytochrome c]-lysine N-methyltransferase activity [IDA][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEVFRFYSN SRNIFIHKSL SLKPSTIDDP KSGYGLFVEP SKFKNDELKS ETIQLLRIPK  60
   61 RCTFNINTLL ALLGDEDEFS SKEEFQRTND KIKIALREIM AHPNFSVFLT ETNLLIIYFM 120
  121 IFQTIRSRYE IPENIQYYLE NVLMSIEVET AMDSIENLAT DYGHYPQIFG LRETLNLFKE 180
  181 LFHDVLNLSD IKHLYSAIIS RCLEIPERAD TKSEEFTVHS TLVPIVDFAN HEGTQKNAYF 240
  241 DIDPSNNDVL LLLDTKAVQS ELTKPIEVFI SYSPTEDLFS MLVTYGFTPD FRGNSQFWTV 300
  301 SFDRCFLRNY DGPDKTTNLR LFYKWMHINP VVPLVKYEHN GKTRWFLNDT TPEFDMLLLP 360
  361 FIPSIDDGKI ARWAYDSTCH LMFTKIHCLI NPEANEHALM IAENYRSLIK EKESNGDDFI 420
  421 NLPPLAWSLR YKDTENDCVR QRHICSEDAV AVLKQEEMQD STKTKSQFTS FFRKFLEFRR 480
  481 SKIIRPTSDS KVASILYQQE LEIIADLAKA IDSSSTIFFS DLNVTLDTEP ERLPPLRFLD 540
  541 DYIEISADKQ EPSPICEDLS YYTPSRFTDF FQEEVSQYAA FFQDD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	NAF1	No Comments	Hazbun TR, et al. (2003)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YGR190C	CTM1	1	Unpublished Fields Lab Data
View Screen	ADH2	CTM1	1	Unpublished Fields Lab Data
View Screen	APC5	CTM1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..585]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
protein methyltransferase activity	4.97781355650779	bayes_pls_golite062009
histone methyltransferase activity	4.89128604457075	bayes_pls_golite062009
lysine N-methyltransferase activity	4.13829019654676	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	4.13829019654676	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	4.13829019654676	bayes_pls_golite062009
N-methyltransferase activity	2.87910762266807	bayes_pls_golite062009
histone methyltransferase activity (H3-K9 specific)	2.45015175643467	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.39062975446297	bayes_pls_golite062009
methyltransferase activity	2.04334127011119	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	1.97073056135916	bayes_pls_golite062009
transferase activity	1.26319468900595	bayes_pls_golite062009
protein binding	1.02960900993633	bayes_pls_golite062009
binding	1.00878369833728	bayes_pls_golite062009
nucleic acid binding	0.427423740181636	bayes_pls_golite062009
catalytic activity	0.414880787313138	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2