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Protein Overview: GRE3

General Information:
Name(s) found: GRE3 / YHR104W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Aldose reductase involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 327 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: arabinose catabolic process [IDALink to PubMed article][IMPLink to PubMed article]
    response to stress [IDALink to PubMed article]
    D-xylose catabolic process [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: aldehyde reductase activity [IDALink to PubMed articleLink to PubMed article]
    aldo-keto reductase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLVTLNNG LKMPLVGLGC WKIDKKVCAN QIYEAIKLGY RLFDGACDYG NEKEVGEGIR  60
   61 KAISEGLVSR KDIFVVSKLW NNFHHPDHVK LALKKTLSDM GLDYLDLYYI HFPIAFKYVP 120
  121 FEEKYPPGFY TGADDEKKGH ITEAHVPIID TYRALEECVD EGLIKSIGVS NFQGSLIQDL 180
  181 LRGCRIKPVA LQIEHHPYLT QEHLVEFCKL HDIQVVAYSS FGPQSFIEMD LQLAKTTPTL 240
  241 FENDVIKKVS QNHPGSTTSQ VLLRWATQRG IAVIPKSSKK ERLLGNLEIE KKFTLTEQEL 300
  301 KDISALNANI RFNDPWTWLD GKFPTFA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GRE3 PCH2 PMC1
    View Details Qiu et al. (2008) GCY1 GRE3 YJR096W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GRE3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..327] PSI-BLAST 1135.0 Xylose reductase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • aldehyde reductase activity
    		•  5.07106269693426 bayes_pls_golite062009
  • L-glucuronate reductase activity
    		•  4.06568552614053 bayes_pls_golite062009
  • arabinose reductase activity
    		•  3.28910924444005 bayes_pls_golite062009
  • xylose reductase activity
    		•  3.28910924444005 bayes_pls_golite062009
  • glucose 1-dehydrogenase (NADP+) activity
    		•  2.68048267823456 bayes_pls_golite062009
  • aldo-keto reductase activity
    		•  2.57303336304449 bayes_pls_golite062009
  • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
    		•  2.43245618396666 bayes_pls_golite062009
  • 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity
    		•  2.43245618396666 bayes_pls_golite062009
  • alpha-keto ester reductase activity
    		•  2.31616201247794 bayes_pls_golite062009
  • alpha-keto amide reductase activity
    		•  2.31616201247794 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  2.19555484888528 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.87468990921314 bayes_pls_golite062009
  • catalytic activity
    		•  1.68179794468736 bayes_pls_golite062009
  • glucose 1-dehydrogenase activity
    		•  1.55697325009049 bayes_pls_golite062009
  • bile acid transmembrane transporter activity
    		•  1.47447940903315 bayes_pls_golite062009
  • monocarboxylic acid transmembrane transporter activity
    		•  1.45034485133104 bayes_pls_golite062009
  • binding
    		•  1.3044513338497 bayes_pls_golite062009
  • bile acid binding
    		•  1.28757511368757 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.22645031212774 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  1.20678148401125 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  1.19919645230426 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-CH group of donors
    		•  1.15597377782029 bayes_pls_golite062009
  • 3-oxo-5-beta-steroid 4-dehydrogenase activity
    		•  1.15597377782029 bayes_pls_golite062009
  • protein binding
    		•  1.06359558718341 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.03420335553507 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.868027162240181 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.86591084281532 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.783004917746429 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.544360068128604 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.260605752589411 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0547047948210824 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle