Protein Overview: COS8

General Information:
Name(s) found:	COS8 / YHL048W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731624\|sp\|P38723.1\|COS8_YEAST RecName: Full=Protein COS8 [NCBI NR] gi\|6321739\|ref\|NP_011815.1\| Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response; Cos8p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S48920 hypothetical protein YHL048w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|2289877\|gb\|AAB65060.1\| nuclear membrane protein [Saccharomyces cerevisiae] [NCBI NR] Protein COS8 OS=Saccharomyces cerevisiae GN=COS8 PE=1 SV=1 [Swiss-Prot] COS8 Nuclear membrane protein, member of a family of conserved, often subtelomerically-encoded proteins [mips] Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response [SGD] COS8, Chr VIII from 6400-7545 [yeast_orfs2] Chr VIII from 6400-7545 [yeastorf3.fasta] (P38723) COS8 protein [4932.FASTACCERV.txt] COS8 SGDID:S0001040, Chr VIII from 6400-7545, Verified ORF [yeastflysequest.fasta] Cos8p [Saccharomyces cerevisiae]gi\|731624\|sp\|P38723\|COS8_YEAST COS8 proteingi\|2289877\|gb\|AAB65060.1\| YHL048w gene product [Saccharomyces cerevisiae]gi\|626590\|pir\|\|S48920 hypothetical protein YHL048w - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] COS8 SGDID:S000001040, Chr VIII from 6400-7545, Verified ORF, "Nuclear membrane protein, member of a family of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] COS8 SGDID:S000001040, Chr VIII from 6400-7545, Verified ORF, "Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response" [yeast-contam.fasta] nuclear membrane protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response; Cos8p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein COS8 [nr-271106-contam.fasta] [chemostatdb.fasta] Protein COS8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COS8 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] COS8 SGDID:S000001040, Chr VIII from 6401-7546, Genome Release 64-1-1, Verified ORF, "Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response" [yeast-030211-contam.fasta] COS8 SGDID:S000001040, Chr VIII from 6401-7546, Genome Release 64-2-1, Verified ORF, "Nuclear membrane protein; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response" [20141208_orf_trans.fasta] YHL048W SGDID:S000001040, Chr VIII from 6401-7546, Genome Release 64-1-1, Verified ORF, "Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	381 amino acids
Gene Ontology:
Cellular Component:	nuclear envelope [IDA]
Biological Process:	response to unfolded protein [IEP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKENEVKDEK SVDVLSFKQL EFQKTVLPQD VFRNELTWFC YEIYKSLAFR IWMLLWLPLS  60
   61 VWWKLSSNWI HPLIVSLLVL FLGPFFVLVI CGLSRKRSLS KQLIQFCKEI TEDTPSSDPH 120
  121 DWEVVAANLN SYFYENKTWN TKYFFFNAMS CQKAFKTTLL EPFSLKKDES AKVKSFKDSV 180
  181 PYIEEALQVY AAGFDKEWKL FNTEKEESPF DLEDIQLPKE AYRFKLTWIL KRIFNLRCLP 240
  241 LFLYYFLIVY TSGNADLISR FLFPVVMFFI MTRDFQNMRM IVLSVKMEHK MQFLSTIINE 300
  301 QESGANGWDE IAKKMNRYLF EKKVWNNEEF FYDGLDCEWF FRRFFYRLLS LKKPMWFASL 360
  361 NVELWPYIKE AQSARNEKPL K

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	COS8	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..61]	MSA	1.017984	View MSA. No confident structure predictions are available.
2	View Details	[62..168]	Pfam	49.309804	DUP family Confident ab initio structure predictions are available.
3	View Details	[169..239]	deduced	N/A	No confident structure predictions are available.
4	View Details	[240..381]	Pfam	59.79588	DUP family No confident structure predictions are available.

Protein Overview: COS8

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: