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View Structure Prediction Details

Protein: COS8
Organism: Saccharomyces cerevisiae
Length: 381 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COS8.

Description E-value Query
Range
Subject
Range
COS1 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-enc...
COS1_YEAST - Protein COS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COS1 PE=1 SV=1
597.0 [0..1] [380..1]

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Predicted Domain #1
Region A:
Residues: [1-61]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKENEVKDEK SVDVLSFKQL EFQKTVLPQD VFRNELTWFC YEIYKSLAFR IWMLLWLPLS  60
   61 V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [62-168]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WWKLSSNWIH PLIVSLLVLF LGPFFVLVIC GLSRKRSLSK QLIQFCKEIT EDTPSSDPHD  60
   61 WEVVAANLNS YFYENKTWNT KYFFFNAMSC QKAFKTTLLE PFSLKKD

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 49.309804
Match: PF00674
Description: DUP family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.820 N/A N/A a.64.1 Saposin

Predicted Domain #3
Region A:
Residues: [169-239]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESAKVKSFKD SVPYIEEALQ VYAAGFDKEW KLFNTEKEES PFDLEDIQLP KEAYRFKLTW  60
   61 ILKRIFNLRC L

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [240-381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLFLYYFLIV YTSGNADLIS RFLFPVVMFF IMTRDFQNMR MIVLSVKMEH KMQFLSTIIN  60
   61 EQESGANGWD EIAKKMNRYL FEKKVWNNEE FFYDGLDCEW FFRRFFYRLL SLKKPMWFAS 120
  121 LNVELWPYIK EAQSARNEKP LK

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 59.79588
Match: PF00674
Description: DUP family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle