Protein Overview: COS6

General Information:
Name(s) found:	COS6 / YGR295C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321734\|ref\|NP_011811.1\| Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos6p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S64632 probable membrane protein YGR295c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1723791\|sp\|P53344.1\|COS6_YEAST RecName: Full=Protein COS6 [NCBI NR] gi\|1323539\|emb\|CAA97328.1\| COS6 [Saccharomyces cerevisiae] [NCBI NR] Protein COS6 OS=Saccharomyces cerevisiae GN=COS6 PE=1 SV=1 [Swiss-Prot] COS6 Member of a family of conserved, often subtelomerically-encoded proteins [mips] Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [SGD] COS6, Chr VII from 1081581-1082726, reverse complement [yeast_orfs2] Chr VII from 1081581-1082726, reverse complement [yeastorf3.fasta] Chr VII from 1081588-1082733, reverse complement [yeastorf4.fasta] Chr VII from 1082733-1081588, reverse complement [yeastorf5.fasta] (P53344) COS6 protein [4932.FASTACCERV.txt] COS6 SGDID:S0003527, Chr VII from 1082734-1081589, reverse complement, Verified ORF [yeastflysequest.fasta] COS6 SGDID:S0003527, Chr VII from 1082735-1081590, reverse complement, Verified ORF [10112005cervSGD.fasta] Cos6p [Saccharomyces cerevisiae]gi\|1323539\|emb\|CAA97328.1\| COS6 [Saccharomyces cerevisiae]gi\|2132641\|pir\|\|S64632 probable membrane protein YGR295c - yeast (Saccharomyces cerevisiae)gi\|1723791\|sp\|P53344\|COS6_YEAST COS6 protein [nrdb_11152004_Chlamydomonas] COS6 SGDID:S000003527, Chr VII from 1082735-1081590, reverse complement, Verified ORF, "Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] COS6 SGDID:S000003527, Chr VII from 1082735-1081590, reverse complement, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins" [yeast-contam.fasta] COS6 SGDID:S000003527, Chr VII from 1082736-1081591, reverse complement, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] COS6 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein COS6 [nr-271106-contam.fasta] [chemostatdb.fasta] Protein COS6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COS6 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] COS6 SGDID:S000003527, Chr VII from 1082729-1081584, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins" [yeast-030211-contam.fasta] COS6 SGDID:S000003527, Chr VII from 1082729-1081584, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins" [20141208_orf_trans.fasta] YGR295C SGDID:S000003527, Chr VII from 1082729-1081584, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	381 amino acids
Gene Ontology:
Cellular Component:	fungal-type vacuole [IDA]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKENELKNEK SVDVLSVKQL ESQKTVLPQD LFRSSFTWFC YEIYKSLVFR IWMLLWLPLS  60
   61 VWWKLSNNWI YPLMVSLLVL FWGPVFVLVI FRLSRKRSLS KQLTQFCKEI TKNTPSSDPH 120
  121 DWEVVAANLN SYFYENKAWN TKYFFFSAMS CQEAFRTTLL EPFSLKKDEA AKVKSFKDSV 180
  181 PYIEEALEVY FTEVEKQWKL FNSEKSWSPV GLEDAKLPKE AYRFKLTWVL KRIFNRRCLP 240
  241 LFLFYLHNVF ISRNDGTIAR PLFLVVLFFI MTRDFRNMRM IVLSVKMEHK MQFLSTIINE 300
  301 QESGANGWDE IAKKMNRYLF EKKVWKNEEF FFDGIDCEWF FSHFFYRVLS AKKSMRALSL 360
  361 NVELWPYIKE AQLSCSEESL A

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		COS2, COS3 COS6

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	VAM3	Sample: HX14 - mixture in detergent (control).	Hao Xu, et al. (2010)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	COS6	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..61]	MSA	1.018984	View MSA. No confident structure predictions are available.
2	View Details	[62..169]	Pfam	48.251812	DUP family Confident ab initio structure predictions are available.
3	View Details	[170..241]	deduced	N/A	No confident structure predictions are available.
4	View Details	[242..381]	Pfam	58.744727	DUP family No confident structure predictions are available.

Protein Overview: COS6

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: