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Protein Overview: LSC2

General Information:
Name(s) found: LSC2 / YGR244C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 427 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: tricarboxylic acid cycle [TASLink to PubMed article]
    succinyl-CoA metabolic process [IDALink to PubMed article][TASLink to PubMed article]
    Molecular Function: succinate-CoA ligase (ADP-forming) activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYSRKSLSLI SKCGQLSRLN AQAALQARRH LSIHEYRSAQ LLREYGIGTP EGFPAFTPEE  60
   61 AFEAAKKLNT NKLVIKAQAL TGGRGKGHFD TGYKSGVHMI ESPQQAEDVA KEMLNHNLIT 120
  121 KQTGIAGKPV SAVYIVKRVD TKHEAYLSIL MDRQTKKPMI IASSQGGMNI EEVAERTPDA 180
  181 IKKFSIETSK GLSPQMAKDV AKSLGFSPDA QDEAAKAVSN LYKIFMERDA TQVEINPLSE 240
  241 IEHDPTHKIM CTDAKFGFDD NASFRQEKIY SWRDLSQEDP DEVKAKKYDL NFVKLKGNIG 300
  301 CLVNGAGLAM ATMDVIKLNG GDPANFLDCG GGATPETIKQ GFELILSNKN VDAIFVNIFG 360
  361 GIVRCDYVAL GLVEAARELE VRVPIVARLQ GTKVEEGRDI INKSGVKIYS FDELDPAAKK 420
  421 VVELTQN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) LSC1 LSC2
    View Details Krogan NJ, et al. (2006) LSC1 LSC2
    View Details Qiu et al. (2008) LSC1 LSC2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LSC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..50]
    [139..278]    		 PSI-BLAST 1084.9691 Succinyl-CoA synthetase, beta-chain, C-terminal domain; Succinyl-CoA synthetase, beta-chain, N-terminal domain
    2 View Details [51..138]
    [279..427]    		 PSI-BLAST 1084.9691 Succinyl-CoA synthetase, beta-chain, C-terminal domain; Succinyl-CoA synthetase, beta-chain, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • succinate-CoA ligase (GDP-forming) activity
    		•  9.38156037766008 bayes_pls_golite062009
  • succinate-CoA ligase activity
    		•  9.37213380498009 bayes_pls_golite062009
  • CoA-ligase activity
    		•  8.19630272128785 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  7.98453115335343 bayes_pls_golite062009
  • succinate-CoA ligase (ADP-forming) activity
    		•  7.27105019329796 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  7.23103788464777 bayes_pls_golite062009
  • ligase activity
    		•  3.25077459445999 bayes_pls_golite062009
  • ATP citrate synthase activity
    		•  3.09252003125984 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  3.07329302783164 bayes_pls_golite062009
  • catalytic activity
    		•  2.5009559386228 bayes_pls_golite062009
  • CoA carboxylase activity
    		•  1.75094739650292 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  1.59015373957506 bayes_pls_golite062009
  • acetyl-CoA carboxylase activity
    		•  1.29064883699349 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.15639517822408 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.992008268375695 bayes_pls_golite062009
  • binding
    		•  0.346654244533873 bayes_pls_golite062009
  • biotin carboxylase activity
    		•  0.0172732430077291 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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