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Protein Overview: MDR1

General Information:
Name(s) found: MDR1 / YGR100W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 950 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [TASLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: intracellular protein transport [IGILink to PubMed article]
    Molecular Function: Rab GTPase activator activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFFDSLRQK APFLDKLADS FTPTLTRDEK FRLKYKLPAN ENILEDTNAE VSFATSIKDG  60
   61 KGHSDRVNNK GRKTAYVYSG RLFLTPHFLV FRDAFDHSSC VLILNISTIK RVERSPSESY 120
  121 EFALLVTLYT GAKVLIQFIG IRYRSEQFCD KLKLNLKENI PNAKTLPAFL ETSYSEFLIA 180
  181 KNILGKKDIT VPRAGLGQHF KYPGNPTMVK EKAKLRLWFD YFRENGRNLA VVQTPMFRKL 240
  241 IRIGVPNRMR GEIWELCSGA MYMRYANSGE YERILNENAG KTSQAIDEIE KDLKRSLPEY 300
  301 SAYQTEEGIQ RLRNVLTAYS WKNPDVGYCQ AMNIVVAGFL IFMSEEQAFW CLCNLCDIYV 360
  361 PGYYSKTMYG TLLDQRVFES FVEDRMPVLW EYILQHDIQL SVVSLPWFLS LFFTSMPLEY 420
  421 AVRIMDIFFM NGSITLFQVA LAVLKINADD ILQADDDGMF IAIIKHYFQT LGQSAHPDSS 480
  481 DIKYRQITKF QELLVTAFKE FSVISEEMAM HARHKYEKGI FQNIETFMKR TQLRHMPKTF 540
  541 NLSSDDLSNI YDMFYQSIET YKISMGTGSS NMGFEVFIQF LSKFCDSCRP CEKDKDPAFR 600
  601 KQKRNFLQRL FDNWDSAHIG ELTLNDVVTG LDKLVTVDLL QAINYFFSLY DTDGDGELHR 660
  661 EEVLQLSEGL LLLTEPWKSG RYVDLLTKKR IEDDIAENII KESGGEIATM NQIELPTGVT 720
  721 IDEEKYKVEQ AERYLKAASN FLQRSFEYAK AVDLAEEVNL IDLSDDEGEE KRTVKQKQLE 780
  781 SIKANAALDP THPKVIDLPT FRMIILADET YELFFSNTLR SSVHVDEHVN IDNKNKVLRS 840
  841 MFDGILADGK RVAEQVRRRV DSVATRSSIA SVESTPTAAA SSITTKEEKY DDLDDFTSEH 900
  901 QPENEELLQS SWFEIDDANE TSTKAIQERS FEPLSANSSE EKSNLIEFEA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MDR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..164] Pfam 21.420216 GRAM domain No confident structure predictions are available.
    2 View Details [165..369]
    [423..453]    		 PSI-BLAST 43.154902 Ypt/Rab-GAP domain of gyp1p
    3 View Details [370..422] PSI-BLAST 43.154902 Ypt/Rab-GAP domain of gyp1p
    4 View Details [454..522] deduced N/A No confident structure predictions are available.
    5 View Details [523..637] PSI-BLAST 57.66807 Recoverin
    6 View Details [638..766] PSI-BLAST 57.66807 Recoverin
    7 View Details [767..950] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.08545912858984 bayes_pls_golite062009
  • protein binding
    		•  1.56086942180613 bayes_pls_golite062009
  • calcium ion binding
    		•  1.33959449723205 bayes_pls_golite062009
  • cation binding
    		•  1.09340191610586 bayes_pls_golite062009
  • metal ion binding
    		•  1.09340191610586 bayes_pls_golite062009
  • ion binding
    		•  1.08592956217627 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle