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Protein Overview: UGA1

General Information:
Name(s) found: UGA1 / YGR019W [SGD]
Description(s) found:
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  • gi|6321456|ref|NP_011533.1| Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; Uga1p [Sacc [NCBI NR]
  • gi|51013259|gb|AAT92923.1| YGR019W [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S64310 4-aminobutyrate transaminase (EC 2.6.1.19) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1730199|sp|P17649.2|GATA_YEAST RecName: Full=4-aminobutyrate aminotransferase; AltName: Full=Gamma-amino-N-butyrate transaminase; Short=GABA transaminase; AltName: Full=GABA aminotransferase; Short=GABA-AT [NCBI NR]
  • gi|1322987|emb|CAA97002.1| UGA1 [Saccharomyces cerevisiae] [NCBI NR]
  • 4-aminobutyrate aminotransferase OS=Saccharomyces cerevisiae GN=UGA1 PE=1 SV=2 [Swiss-Prot]
  • UGA1 4-aminobutyrate aminotransferase (GABA transaminase) [mips]
  • Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization [SGD]
  • UGA1, Chr VII from 525223-526638 [yeast_orfs2]
  • Chr VII from 525223-526638 [yeastorf3.fasta]
  • Chr VII from 525230-526645 [yeastorf4.fasta]
  • (P17649) 4-aminobutyrate aminotransferase (EC 2.6.1.19) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA aminotransferase) (GABA-AT) [4932.FASTACCERV.txt]
  • UGA1 SGDID:S0003251, Chr VII from 525231-526646, Verified ORF [yeastflysequest.fasta]
  • UGA1 SGDID:S0003251, Chr VII from 525233-526648, Verified ORF [10112005cervSGD.fasta]
  • Uga1p [Saccharomyces cerevisiae]gi|51013259|gb|AAT92923.1| YGR019W [Saccharomyces cerevisiae]gi|1322987|emb|CAA97002.1| UGA1 [Saccharomyces cerevisiae]gi|2131160|pir||S64310 4-aminobutyrate transaminase (EC 2.6.1.19) - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • UGA1 SGDID:S000003251, Chr VII from 525233-526648, Verified ORF, "Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • UGA1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YGR019W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • 4-aminobutyrate aminotransferase (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA aminotransferase) (GABA-AT) [nr-271106-contam.fasta]
  • Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; Uga1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • UGA1 SGDID:S000003251, Chr VII from 525233-526648, Verified ORF, "Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • UGA1 SGDID:S000003251, Chr VII from 525229-526644, Genome Release 64-1-1, Verified ORF, "Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization" [yeast-030211-contam.fasta]
  • UGA1 SGDID:S000003251, Chr VII from 525229-526644, Genome Release 64-2-1, Verified ORF, "Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta]
  • YGR019W SGDID:S000003251, Chr VII from 525229-526644, Genome Release 64-1-1, Verified ORF, "Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 471 amino acids

    Gene Ontology:
    Cellular Component: intracellular [ICLink to PubMed article]
    Biological Process: nitrogen utilization [TASLink to PubMed article]
    Molecular Function: 4-aminobutyrate transaminase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSICEQYYPE EPTKPTVKTE SIPGPESQKQ LKELGEVFDT RPAYFLADYE KSLGNYITDV  60
   61 DGNTYLDLYA QISSIALGYN NPALIKAAQS PEMIRALVDR PALGNFPSKD LDKILKQILK 120
  121 SAPKGQDHVW SGLSGADANE LAFKAAFIYY RAKQRGYDAD FSEKENLSVM DNDAPGAPHL 180
  181 AVLSFKRAFH GRLFASGSTT CSKPIHKLDF PAFHWPHAEY PSYQYPLDEN SDANRKEDDH 240
  241 CLAIVEELIK TWSIPVAALI IEPIQSEGGD NHASKYFLQK LRDITLKYNV VYIIDEVQTG 300
  301 VGATGKLWCH EYADIQPPVD LVTFSKKFQS AGYFFHDPKF IPNKPYRQFN TWCGEPARMI 360
  361 IAGAIGQEIS DKKLTEQCSR VGDYLFKKLE GLQKKYPENF QNLRGKGRGT FIAWDLPTGE 420
  421 KRDLLLKKLK LNGCNVGGCA VHAVRLRPSL TFEEKHADIF IEALAKSVNE L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 hx21: both fusion and trans-SNARE complex formation take place. Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data UGA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..471] PSI-BLAST 1210.0 4-aminobutyrate aminotransferase, GABA-aminotransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 4-aminobutyrate transaminase activity
    		•  9.08769857759091 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase binding
    		•  8.44659094913875 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  3.359406422625 bayes_pls_golite062009
  • transferase activity
    		•  2.59075614411581 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • adenosylmethionine-8-amino-7-oxononanoate transaminase activity
    		•  1.74778109525713 bayes_pls_golite062009
  • N-succinyltransferase activity
    		•  1.52003194822848 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.46601963907552 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.46601963907552 bayes_pls_golite062009
  • N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
    		•  1.4383564662931 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.19150094103499 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.977210827616757 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.892872530648552 bayes_pls_golite062009
  • binding
    		•  0.892049641082766 bayes_pls_golite062009
  • ligase activity
    		•  0.827063849687833 bayes_pls_golite062009
  • DNA binding
    		•  0.803965264969424 bayes_pls_golite062009
  • kynureninase activity
    		•  0.777830972119923 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  0.698312655247044 bayes_pls_golite062009
  • transcription factor activity
    		•  0.597417107954964 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  0.54326874956263 bayes_pls_golite062009
  • ornithine-oxo-acid transaminase activity
    		•  0.311107335626334 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.2609065149092 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.15938456446406 bayes_pls_golite062009
  • hydrolase activity
    		•  0.158765164178244 bayes_pls_golite062009
  • amine binding
    		•  0.14702601411039 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.103986924428507 bayes_pls_golite062009
  • sulfurtransferase activity
    		•  0.0450490929307473 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.0254276656964899 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle