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Protein Overview: GUS1

General Information:
Name(s) found: GUS1 / YGL245W [SGD]
Description(s) found:
Found 14 descriptions.
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  • Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 724 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    methionyl glutamyl tRNA synthetase complex [IDALink to PubMed article]
    Biological Process: glutamyl-tRNA aminoacylation [IDALink to PubMed article]
    Molecular Function: glutamate-tRNA ligase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKLFSKVKE SIEGIKMPST LTINGKAPIV AYAELIAARI VNALAPNSIA IKLVDDKKAP  60
   61 AAKLDDATED VFNKITSKFA AIFDNGDKEQ VAKWVNLAQK ELVIKNFAKL SQSLETLDSQ 120
  121 LNLRTFILGG LKYSAADVAC WGALRSNGMC GSIIKNKVDV NVSRWYTLLE MDPIFGEAHD 180
  181 FLSKSLLELK KSANVGKKKE THKANFEIDL PDAKMGEVVT RFPPEPSGYL HIGHAKAALL 240
  241 NQYFAQAYKG KLIIRFDDTN PSKEKEEFQD SILEDLDLLG IKGDRITYSS DYFQEMYDYC 300
  301 VQMIKDGKAY CDDTPTEKMR EERMDGVASA RRDRSVEENL RIFTEEMKNG TEEGLKNCVR 360
  361 AKIDYKALNK TLRDPVIYRC NLTPHHRTGS TWKIYPTYDF CVPIVDAIEG VTHALRTIEY 420
  421 RDRNAQYDWM LQALRLRKVH IWDFARINFV RTLLSKRKLQ WMVDKDLVGN WDDPRFPTVR 480
  481 GVRRRGMTVE GLRNFVLSQG PSRNVINLEW NLIWAFNKKV IDPIAPRHTA IVNPVKIHLE 540
  541 GSEAPQEPKI EMKPKHKKNP AVGEKKVIYY KDIVVDKDDA DVINVDEEVT LMDWGNVIIT 600
  601 KKNDDGSMVA KLNLEGDFKK TKHKLTWLAD TKDVVPVDLV DFDHLITKDR LEEDESFEDF 660
  661 LTPQTEFHTD AIADLNVKDM KIGDIIQFER KGYYRLDALP KDGKPYVFFT IPDGKSVNKY 720
  721 GAKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NAF1 No Comments Hazbun TR, et al. (2003)
    View Run HSL7 No Comments McCusker D, et al (2007)
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128] MSA 3.098986 View MSA. No confident structure predictions are available.
    2 View Details [129..193] PSI-BLAST 3.221849 Arginyl-tRNA synthetase (ArgRS); Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
    3 View Details [194..446] PSI-BLAST 1009.228787 Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain; Glutaminyl-tRNA synthetase (GlnRS)
    4 View Details [447..518]
    [642..666]    		 PSI-BLAST 1009.228787 Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain; Glutaminyl-tRNA synthetase (GlnRS)
    5 View Details [519..641]
    [667..724]    		 PSI-BLAST 1009.228787 Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain; Glutaminyl-tRNA synthetase (GlnRS)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle