Protein Overview: SUA5

General Information:
Name(s) found:	SUA5 / YGL169W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|971384\|emb\|CAA59760.1\| G1660 [Saccharomyces cerevisiae] [NCBI NR] gi\|6321269\|ref\|NP_011346.1\| Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start; Sua5p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S41991 SUA5 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|4566\|emb\|CAA45598.1\| SUA5 [Saccharomyces cerevisiae] [NCBI NR] gi\|417826\|sp\|P32579.1\|SUA5_YEAST RecName: Full=Protein SUA5 [NCBI NR] gi\|1322770\|emb\|CAA96881.1\| SUA5 [Saccharomyces cerevisiae] [NCBI NR] Protein SUA5 OS=Saccharomyces cerevisiae GN=SUA5 PE=1 SV=1 [Swiss-Prot] SUA5 Translation initiation protein [mips] Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family [SGD] SUA5, Chr VII from 186063-187343 [yeast_orfs2] Chr VII from 186063-187343 [yeastorf3.fasta] (P32579) SUA5 protein [4932.FASTACCERV.txt] SUA5 SGDID:S0003137, Chr VII from 186063-187343, Verified ORF [yeastflysequest.fasta] SUA5 SGDID:S0003137, Chr VII from 186065-187345, Verified ORF [10112005cervSGD.fasta] Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start [Saccharomyces cerevisiae]gi\|1322770\|emb\|CAA96881.1\| SUA5 [Saccharomyces cerevisi [nrdb_11152004_Chlamydomonas] SUA5 SGDID:S000003137, Chr VII from 186065-187345, Verified ORF, "Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] SUA5 SGDID:S000003137, Chr VII from 186065-187345, Verified ORF, "Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding [SGD_S-cerevisiae_na_05-08-2009_con_reversed.fasta] G1660 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SUA5 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start; Sua5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein SUA5 [nr-271106-contam.fasta] SUA5 SGDID:S000003137, Chr VII from 186065-187345, Verified ORF, "Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family" [scerevisihumanrev.fasta] [chemostatdb.fasta] tRNA threonylcarbamoyladenosine biosynthesis protein SUA5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SUA5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SUA5 SGDID:S000003137, Chr VII from 186059-187339, Genome Release 64-1-1, Verified ORF, "Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family" [yeast-030211-contam.fasta] SUA5 SGDID:S000003137, Chr VII from 186059-187339, Genome Release 64-2-1, Verified ORF, "Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; binds single-stranded telomeric DNA and null mutant has abnormal telomere length" [20141208_orf_trans.fasta] YGL169W SGDID:S000003137, Chr VII from 186059-187339, Genome Release 64-1-1, Verified ORF, "Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] Threonylcarbamoyl-AMP synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SUA5 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
Organism:	Saccharomyces cerevisiae
Length:	426 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	aerobic respiration [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYLGRHFLAM TSKALFDTKI LKVNPLSIIF SPDAHIDGSL PTITDPETEA ALVEAARIIR  60
   61 DTDETVAFPT ETVYGLGGSA LNDNSVLSIY RAKNRPSDNP LITHVSSIDQ LNRKVFNQPH 120
  121 LSGTSLFDNI PSIYRPLISS LWPGPLTILL PVPSSEHSAL SKLTTADQPT FAVRIPANPV 180
  181 ARALIALSDT PIAAPSANAS TRPSPTLASH VYHDLKDKIP IILDGGACKV GVESTVVDGL 240
  241 CNPPTLLRPG GFTYEEIVKL GGEAWSLCKV ENKKTVEKGE KVRTPGMKYR HYSPSAKVVL 300
  301 LVPHCEGDGI LKGVDRMERL KRLIETELKA NSNIKKIAIL TSLKLRDSDL QSKIFNEPDF 360
  361 SSKTFIIERL GQSGEEIQTN LFAALRKVDE NDKVDLIFVE GINEEGEGLA VMNRLRKAAA 420
  421 NNCIQF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ORC3	SUA5	2	Unpublished Fields Lab Data
View Screen	HO	SUA5	1	Unpublished Fields Lab Data
View Screen	RPN11	SUA5	1	Unpublished Fields Lab Data
View Screen	MET18	SUA5	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SUA5	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..249]	PSI-BLAST	57.69897	Hypothetical protein YciO
2	View Details	[250..285]	MSA	1.469993	View MSA. No confident structure predictions are available.
3	View Details	[286..426]	PSI-BLAST	20.0	No description for 2yv4A was found.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2