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Protein Overview: ARO2

General Information:
Name(s) found: ARO2 / YGL148W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 376 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: aromatic amino acid family biosynthetic process [IMPLink to PubMed article]
    Molecular Function: flavin reductase activity [IDALink to PubMed article]
    chorismate synthase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTFGKLFRV TTYGESHCKS VGCIVDGVPP GMSLTEADIQ PQLTRRRPGQ SKLSTPRDEK  60
   61 DRVEIQSGTE FGKTLGTPIA MMIKNEDQRP HDYSDMDKFP RPSHADFTYS EKYGIKASSG 120
  121 GGRASARETI GRVASGAIAE KFLAQNSNVE IVAFVTQIGE IKMNRDSFDP EFQHLLNTIT 180
  181 REKVDSMGPI RCPDASVAGL MVKEIEKYRG NKDSIGGVVT CVVRNLPTGL GEPCFDKLEA 240
  241 MLAHAMLSIP ASKGFEIGSG FQGVSVPGSK HNDPFYFEKE TNRLRTKTNN SGGVQGGISN 300
  301 GENIYFSVPF KSVATISQEQ KTATYDGEEG ILAAKGRHDP AVTPRAIPIV EAMTALVLAD 360
  361 ALLIQKARDF SRSVVH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RPN9 ARO2 1 Unpublished Fields Lab Data
    View Screen HMG1 ARO2 1 Unpublished Fields Lab Data
    View Screen RPB2 ARO2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ARO2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..376] ORFEUS 7.01 Phosphoglycerate kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • chorismate synthase activity
    		•  5.15976990017342 bayes_pls_golite062009
  • carbon-oxygen lyase activity, acting on phosphates
    		•  4.26558071446785 bayes_pls_golite062009
  • catalytic activity
    		•  1.94308403509017 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  1.59965915025616 bayes_pls_golite062009
  • lyase activity
    		•  1.53765291169529 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle