Protein Overview: SRM1

General Information:
Name(s) found:	SRM1 / YGL097W [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|RGBYM1 pheromone response pathway component SRM1 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|666950\|gb\|AAA62268.1\| suppressor [Saccharomyces cerevisiae] [NCBI NR] gi\|6321341\|ref\|NP_011418.1\| Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; Srm1p [Saccharomy [NCBI NR] gi\|1322633\|emb\|CAA96803.1\| SRM1 [Saccharomyces cerevisiae] [NCBI NR] gi\|132174\|sp\|P21827.1\|RCC1_YEAST RecName: Full=Regulator of chromosome condensation; AltName: Full=Protein PRP20; AltName: Full=Pheromone response pathway component SRM1 [NCBI NR] Regulator of chromosome condensation OS=Saccharomyces cerevisiae GN=PRP20 PE=1 SV=1 [Swiss-Prot] SRM1 GDP/GTP exchange factor for Gsp1p/Gsp2p [mips] Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p [SGD] SRM1, Chr VII from 321780-323228 [yeast_orfs2] Chr VII from 321780-323228 [yeastorf3.fasta] Chr VII from 321783-323231 [yeastorf4.fasta] (P21827) Regulator of chromosome condensation (PRP20 protein) (Pheromone response pathway component SRM1) [4932.FASTACCERV.txt] SRM1 SGDID:S0003065, Chr VII from 321783-323231, Verified ORF [yeastflysequest.fasta] SRM1 SGDID:S0003065, Chr VII from 321785-323233, Verified ORF [10112005cervSGD.fasta] Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; potentially phosphorylated by Cdc28p [Saccharomyces cerevisiae]gi\|1322633\|emb\|CAA96803.1\| SRM1 [Saccharomyces cerevisiae]gi\|732 [nrdb_11152004_Chlamydomonas] SRM1 SGDID:S000003065, Chr VII from 321785-323233, Verified ORF, "Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; potentially phosphorylated by Cdc28p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] SRM1 SGDID:S000003065, Chr VII from 321785-323233, Verified ORF, "Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosp [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] SRM1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] suppressor [nr-271106-contam.fasta] Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; potentially phosphorylated by Cdc28p; Srm1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Regulator of chromosome condensation (Protein PRP20) (Pheromone response pathway component SRM1) [nr-271106-contam.fasta] SRM1 SGDID:S000003065, Chr VII from 321785-323233, Verified ORF, "Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Guanine nucleotide exchange factor SRM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRM1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SRM1 SGDID:S000003065, Chr VII from 321782-323230, Genome Release 64-1-1, Verified ORF, "Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p" [yeast-030211-contam.fasta] SRM1 SGDID:S000003065, Chr VII from 321782-323230, Genome Release 64-2-1, Verified ORF, "Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p" [20141208_orf_trans.fasta] YGL097W SGDID:S000003065, Chr VII from 321782-323230, Genome Release 64-1-1, Verified ORF, "Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	482 amino acids
Gene Ontology:
Cellular Component:	nucleus [TAS] nuclear chromatin [IDA]
Biological Process:	rRNA export from nucleus [IMP] ribosomal subunit export from nucleus [IMP]
Molecular Function:	signal transducer activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKRTVATNG DASGAHRAKK MSKTHASHII NAQEDYKHMY LSVQPLDIFC WGTGSMCELG  60
   61 LGPLAKNKEV KRPRLNPFLP RDEAKIISFA VGGMHTLALD EESNVWSWGC NDVGALGRDT 120
  121 SNAKEQLKDM DADDSSDDED GDLNELESTP AKIPRESFPP LAEGHKVVQL AATDNMSCAL 180
  181 FSNGEVYAWG TFRCNEGILG FYQDKIKIQK TPWKVPTFSK YNIVQLAPGK DHILFLDEEG 240
  241 MVFAWGNGQQ NQLGRKVMER FRLKTLDPRP FGLRHVKYIA SGENHCFALT KDNKLVSWGL 300
  301 NQFGQCGVSE DVEDGALVTK PKRLALPDNV VIRSIAAGEH HSLILSQDGD LYSCGRLDMF 360
  361 EVGIPKDNLP EYTYKDVHGK ARAVPLPTKL NNVPKFKSVA AGSHHSVAVA QNGIAYSWGF 420
  421 GETYAVGLGP FEDDTEVPTR IKNTATQDHN IILVGCGGQF SVSGGVKLSD EDAEKRADEM 480
  481 DD

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		GSP1 GSP2 SRM1
View Details	Krogan NJ, et al. (2006)		GSP1 SRM1 YNL247W
View Details	Ho Y, et al. (2002)		GSP1 GSP2 HOM3 MOG1 RNA1 SRM1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	SRM1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..482]	PSI-BLAST	448.228787	Regulator of chromosome condensation RCC1

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: SRM1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: