Protein Overview: STE2

General Information:
Name(s) found:	STE2 / YFL026W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|836728\|dbj\|BAA09212.1\| pheromone alpha factor receptor [Saccharomyces cerevisiae] [NCBI NR] gi\|14318493\|ref\|NP_116627.1\| Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells; [NCBI NR] pir\|\|S56228 alpha-factor receptor - yeast (Saccharomyces cerevisiae) [NCBI NR] STE2 Pheromone alpha-factor receptor [mips] Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells [SGD] STE2, Chr VI from 82578-83873 [yeast_orfs2] Chr VI from 82578-83873 [yeastorf3.fasta] STE2 SGDID:S0001868, Chr VI from 82578-83873, Verified ORF [yeastflysequest.fasta] Ste2p [Saccharomyces cerevisiae]gi\|1084822\|pir\|\|S56228 alpha-factor receptor - yeast (Saccharomyces cerevisiae)gi\|836728\|dbj\|BAA09212.1\| pheromone alpha factor receptor [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] STE2 SGDID:S000001868, Chr VI from 82578-83873, Verified ORF, "Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating b [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells; Ste2p [Saccharomyces cerevisi [nr-271106-contam.fasta] pheromone alpha factor receptor [Saccharomyces cerevisiae] [nr-271106-contam.fasta] STE2 SGDID:S000001868, Chr VI from 82578-83873, Verified ORF, "Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells" [yeast-bovrabprots.fasta] [chemostatdb.fasta]
Organism:	Saccharomyces cerevisiae
Length:	431 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [IDA]
Biological Process:	response to pheromone involved in conjugation with cellular fusion [TAS] cell projection assembly [IMP]
Molecular Function:	mating-type alpha-factor pheromone receptor activity [IDA][IGI][IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDAAPSLSN LFYDPTYNPG QSTINYTSIY GNGSTITFDE LQGLVNSTVT QAIMFGVRCG  60
   61 AAALTLIVMW MTSRSRKTPI FIINQVSLFL IILHSALYFK YLLSNYSSVT YALTGFPQFI 120
  121 SRGDVHVYGA TNIIQVLLVA SIETSLVFQI KVIFTGDNFK RIGLMLTSIS FTLGIATVTM 180
  181 YFVSAVKGMI VTYNDVSATQ DKYFNASTIL LASSINFMSF VLVVKLILAI RSRRFLGLKQ 240
  241 FDSFHILLIM SCQSLLVPSI IFILAYSLEP NQGTDVLTTV ATLLAVLSLP LSSMWATAAN 300
  301 NASKTNTITS DFTTSTDRFY PGTLSSFQTD SINNDAKSSL RSRLYDLYPR RKETTSDKHS 360
  361 ERTFVSETAD DIEKNQFYQL PTPTSSKNTR IGPFADASYK EGEVEPVDMY TPDTAADEEA 420
  421 RKFWTEDNNN L

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ACB1 ADE13 BI2 FRE7 KNS1 NUP170 STE2
View Details	Qiu et al. (2008)		STE2 STE3 STE4

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	AZF1	STE2	1	Unpublished Fields Lab Data
View Screen	PPM1	STE2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	STE2	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..431]	Pfam	1000.0	Fungal pheromone mating factor STE2 GPCR No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2