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Protein Overview: BST1

General Information:
Name(s) found: BST1 / YFL025C [SGD]
Description(s) found:
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  • gi|836729|dbj|BAA09213.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|14318494|ref|NP_116628.1| GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo [NCBI NR]
  • gi|1175934|sp|P43571.1|BST1_YEAST RecName: Full=GPI inositol-deacylase; AltName: Full=Bypass of SEC30 protein 1 [NCBI NR]
  • pir||S56229 probable membrane protein YFL025c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • (P43571) Hypothetical 117.8 kDa protein in STE2-FRS2 intergenic region [Swiss-Prot]
  • GPI inositol-deacylase OS=Saccharomyces cerevisiae GN=BST1 PE=1 SV=1 [Swiss-Prot]
  • BST1 Negative regulator of COPII vesicle formation [mips]
  • GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules [SGD]
  • BST1, Chr VI from 84143-87232, reverse complement [yeast_orfs2]
  • Chr VI from 84143-87232, reverse complement [yeastorf3.fasta]
  • Chr VI from 87232-84143, reverse complement [yeastorf5.fasta]
  • BST1 SGDID:S0001869, Chr VI from 87232-84143, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Bst1p [Saccharomyces cerevisiae]gi|1175934|sp|P43571|YFC5_YEAST Hypothetical 117.8 kDa protein in STE2-FRS2 intergenic regiongi|1084690|pir||S56229 probable membrane protein YFL025c - yeast (Saccharomyces cerevisiae)gi|836729|dbj|BAA09213.1| YFL025C [S [nrdb_11152004_Chlamydomonas]
  • BST1 SGDID:S000001869, Chr VI from 87232-84143, reverse complement, Verified ORF, "GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discriminat [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; Bst1p [Saccharomy [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Hypothetical 117.8 kDa protein in STE2-FRS2 intergenic region [nr-271106-contam.fasta]
  • BST1 SGDID:S000001869, Chr VI from 87232-84143, reverse complement, Verified ORF, "GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • GPI inositol-deacylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BST1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • BST1 SGDID:S000001869, Chr VI from 87234-84145, Genome Release 64-1-1, reverse complement, Verified ORF, "GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules" [yeast-030211-contam.fasta]
  • BST1 SGDID:S000001869, Chr VI from 87234-84145, Genome Release 64-2-1, reverse complement, Verified ORF, "GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; functional ortholog of human PGAP1, mutation of which is associated with intellectual disability and encephalopathy" [20141208_orf_trans.fasta]
  • YFL025C SGDID:S000001869, Chr VI from 87234-84145, Genome Release 64-1-1, reverse complement, Verified ORF, "GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1029 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [ISSLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: GPI anchor metabolic process [IGILink to PubMed article]
    sinus venosus formation [IGILink to PubMed article]
    ER to Golgi vesicle-mediated transport [IMPLink to PubMed article]
    vesicle organization [IGILink to PubMed article][IMPLink to PubMed article]
    ER-associated protein catabolic process [IMPLink to PubMed article]
    protein retention in ER lumen [IMPLink to PubMed article]
    Molecular Function: phosphatidylinositol deacylase activity [IGI]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIRRLVSVI TRPIINKVNS SGQYSRVLAT REDQDKASPK YMNNDKIAKK PYTYRLFSIL  60
   61 GILSICSLLL ISLLKPFNGA DAPQCESIYM FPSYARIDGF DERYTPLAHK YHLYLYREQS 120
  121 VDREPLNGDE LQLDGIPVLF IPGNAGSFRQ CRSIASACSN IYFDSNTRAT LRNENVRNLD 180
  181 FFTADFNEDF TAFHGETMLD QAEYLNDAIK YILSLYERTP DYPHPKPQSV IIVGHSMGGI 240
  241 VSRVMLTLKN HVPGSISTIL TLSSPHAASP VTFDGDILKL YKNTNEYWRK QLSQNDSFFS 300
  301 KNISLVSITG GILDTTLPAD YASVEDLVSL ENGFTSFTTT IPDVWTPIDH LAIVWCKQLR 360
  361 EVLARLLLES IDASKPEKVK PLNQRLQIAR KLLLSGFEDY SWMNSKLNYP QENLQEFSDN 420
  421 FFSDYATLEM NDVLDFEMFN LEKWHNNYTK INIPSNISST EHLHFTLLTS LDMPMIYFCT 480
  481 ESRVNLSCIT AVDSILTVPR SSKDTQFAAD SSFGEAKNPF KAVSVGKNIL QKYDYLMISK 540
  541 PTYGEFSEQE GMEDNQGFLL ALLRNVSNVQ IVNTTPSQIL LFGEQLHLDG KDIEQVISFS 600
  601 NLWDSLLSYK LETKIEASNE GIASEETLFQ PFIRQWVYEP FESKWHLNII NKSLDINMHN 660
  661 VAPFIPLNES EPRSLQLSFF IPPGMSLEAK MTINWSLTLK MLFIRYRLAL ASFPVAFIAL 720
  721 VLSYQFYWYN KTSEFPSFDS TLGYILRKHG ILMFFTLFLA SPVVNNKLVQ RILYLLDPVG 780
  781 LNYPFLLSER NMHANFYYLG IRDWFMSTIG ILFGVMTVGL LALVSKIFGS LEILVIFLQR 840
  841 KLSKKNTEDK EAFDTIEHKA YGKGRLMASV LLLLLVFFHI PYQMAFVISL VIQIATCIRV 900
  901 ALLKLSNNEQ KLNLLNYNMT LLLLLLFVSA INIPIIIVFL HNVAIKWETS FRSHHNILAV 960
  961 APIIFLVGNN SIFKMPNSVP LDTWDGKVTI ILFVYLTVFS FIYGIRNLYW IHHLVNIICA1020
 1021 WLLFFETIH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) BST1 NTE1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data BST1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..396] MSA 3.00692 View MSA. No confident structure predictions are available.
    2 View Details [397..1029] deduced N/A No confident structure predictions are available.
    3 View Details [400..508] deduced N/A No confident structure predictions are available.
    4 View Details [509..671] deduced N/A No confident structure predictions are available.
    5 View Details [672..777] deduced N/A No confident structure predictions are available.
    6 View Details [778..1029] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • hydrolase activity
    		•  2.62575321936198 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.54257949495452 bayes_pls_golite062009
  • catalytic activity
    		•  1.2983708611085 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.05574518895749 bayes_pls_golite062009
  • phospholipase activity
    		•  0.798264075802939 bayes_pls_golite062009
  • peptidase activity
    		•  0.76591567453342 bayes_pls_golite062009
  • binding
    		•  0.453877824078419 bayes_pls_golite062009
  • lipase activity
    		•  0.450520363288288 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0108860947932076 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.00279712309330893 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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