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Protein Overview: JHD1

General Information:
Name(s) found: JHD1 / YER051W [SGD]
Description(s) found:
Found 23 descriptions.
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  • JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: histone demethylation [IDALink to PubMed article]
    Molecular Function: histone demethylase activity (H3-K36 specific) [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQDPNICQHC QLKDNPGALI WVKCDSCPQW VHVKCVPLKR IHYSNLTSSE VLSYPNSAKQ  60
   61 IKSYRCPNHK EGEYLTAYAL ITQKGKRQRN KENPEDSHIN KRYNFRKKKL LDYIALNEGE 120
  121 SKRDKMNHPH KESFMKSFEK WKNGSNIINA ADFAEKFDNI DVPYKIIDPL NSGVYVPNVG 180
  181 TDNGCLTVNY ITEMIGEDYH VDVMDVQSQM NENWNLGSWN EYFTNTEPDR RDRIRNVISL 240
  241 EVSNIEGLEL ERPTAVRQND LVDKIWSFNG HLEKVNGEKA EENDPKPKVT KYILMSVKDA 300
  301 YTDFHLDFAG TSVYYNVISG QKKFLLFPPT QSNIDKYIEW SLKEDQNSVF LGDILEDGIA 360
  361 MELDAGDLFM IPAGYIHAVY TPVDSLVFGG NFLTIRDLET HLKIVEIEKL TKVPRRFTFP 420
  421 KFDQVMGKLC EYLALDKNKI TSDVSDGDLL SRTTNCAIQS LHAYVIKPEV KYKPLNFTSK 480
  481 KHLAKALADL IS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] Pfam 5.036212 PHD-finger No confident structure predictions are available.
    2 View Details [94..284] deduced N/A No confident structure predictions are available.
    3 View Details [285..435] Pfam 2.958607 JmjC domain No confident structure predictions are available.
    4 View Details [436..492] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.88491358085672 bayes_pls_golite062009
  • histone binding
    		•  1.71382360735986 bayes_pls_golite062009
  • histone demethylase activity
    		•  1.42799906837292 bayes_pls_golite062009
  • protein binding
    		•  1.37530480805073 bayes_pls_golite062009
  • methylated histone residue binding
    		•  0.66098532413825 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.238070109642748 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.238070109642748 bayes_pls_golite062009
  • histone demethylase activity (H3-K4 specific)
    		•  0.212310512021675 bayes_pls_golite062009
  • protein kinase activity
    		•  0.0340504798365963 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle