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View Structure Prediction Details

Protein: JHD1
Organism: Saccharomyces cerevisiae
Length: 492 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for JHD1.

Description E-value Query
Range
Subject
Range
JHD1 - JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mous...
JHD1_YEAST - JmjC domain-containing histone demethylation protein 1 OS=Saccharomyces cerevisiae (strain ATCC 2045...
0.0 [1..492] [1..492]
gi|5689559 - gi|5689559|dbj|BAA83063.1| KIAA1111 protein [Homo sapiens]
0.0 [6..434] [64..436]
gi|13938093 - gi|13938093|gb|AAH07161.1| Jhdm1d protein [Mus musculus]
7.0E-96 [28..434] [4..356]
CE09781 - status:Confirmed UniProt:Q9GYI0 protein_id:AAK29799.1
2.0E-88 [17..442] [250..649]
gi|7299136, gi|2... - gi|7299136|gb|AAF54335.1| CG11033 [Drosophila melanogaster], gi|24645257|ref|NP_649864.1| CG11033 [D...
2.0E-87 [88..433] [24..373]
JHD1_SCHPO - Putative JmjC domain-containing histone demethylation protein 1 OS=Schizosaccharomyces pombe (strain...
epe1 - Jmjc domain chromatin associated protein Epe1
3.0E-80 [35..446] [29..441]

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Predicted Domain #1
Region A:
Residues: [1-93]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQDPNICQHC QLKDNPGALI WVKCDSCPQW VHVKCVPLKR IHYSNLTSSE VLSYPNSAKQ  60
   61 IKSYRCPNHK EGEYLTAYAL ITQKGKRQRN KEN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 5.036212
Match: PF00628
Description: PHD-finger

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.88491358085672 bayes_pls_golite062009
histone binding 1.71382360735986 bayes_pls_golite062009
histone demethylase activity 1.42799906837292 bayes_pls_golite062009
protein binding 1.37530480805073 bayes_pls_golite062009
methylated histone residue binding 0.66098532413825 bayes_pls_golite062009
histone acetyltransferase activity 0.238070109642748 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.238070109642748 bayes_pls_golite062009
histone demethylase activity (H3-K4 specific) 0.212310512021675 bayes_pls_golite062009
protein kinase activity 0.0340504798365963 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [94-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEDSHINKRY NFRKKKLLDY IALNEGESKR DKMNHPHKES FMKSFEKWKN GSNIINAADF  60
   61 AEKFDNIDVP YKIIDPLNSG VYVPNVGTDN GCLTVNYITE MIGEDYHVDV MDVQSQMNEN 120
  121 WNLGSWNEYF TNTEPDRRDR IRNVISLEVS NIEGLELERP TAVRQNDLVD KIWSFNGHLE 180
  181 KVNGEKAEEN D

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [285-435]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKPKVTKYIL MSVKDAYTDF HLDFAGTSVY YNVISGQKKF LLFPPTQSNI DKYIEWSLKE  60
   61 DQNSVFLGDI LEDGIAMELD AGDLFMIPAG YIHAVYTPVD SLVFGGNFLT IRDLETHLKI 120
  121 VEIEKLTKVP RRFTFPKFDQ VMGKLCEYLA L

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 2.958607
Match: PF02373
Description: JmjC domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [436-492]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKNKITSDVS DGDLLSRTTN CAIQSLHAYV IKPEVKYKPL NFTSKKHLAK ALADLIS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle