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Protein Overview: ISC1

General Information:
Name(s) found: ISC1 / YER019W [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 477 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: response to salt stress [IMPLink to PubMed article]
    sphingolipid catabolic process [IDALink to PubMed article]
    Molecular Function: phospholipase C activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYNRKDRDVH ERKEDGQSEF EALNGTNAIM SDNSKAYSIK FLTFNTWGLK YVSKHRKERL  60
   61 RAIADKLAGH SMLTPISDEL LPNGGDSNEN EDYDVIALQE IWCVEDWKYL ASACASKYPY 120
  121 QRLFHSGILT GPGLAILSKV PIESTFLYRF PINGRPSAVF RGDWYVGKSI AITVLNTGTR 180
  181 PIAIMNSHMH APYAKQGDAA YLCHRSCQAW DFSRLIKLYR QAGYAVIVVG DLNSRPGSLP 240
  241 HKFLTQEAGL VDSWEQLHGK QDLAVIARLS PLQQLLKGCT TCDSLLNTWR AQRQPDEACR 300
  301 LDYALIDPDF LQTVDAGVRF TERIPHLDCS VSDHFAYSCT LNIVPQGTES RPSTSVKRAK 360
  361 THDRELILQR YSNYETMIEC IHTYLKTAQR QKFFRGLHFW ASILLLIASL VVTTFTANKA 420
  421 GWSSIFWVLF AIAVSISGTI DGAISFLFGR SEIRALIEVE QEVLDAEHHL QTFLSEK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ILM1 ISC1 2 Lockshon D, et al. (2006)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..346] PSI-BLAST 41.39794 DNA repair endonuclease Hap1
    2 View Details [347..477] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • inositol or phosphatidylinositol phosphatase activity
    		•  3.64123197004285 bayes_pls_golite062009
  • phosphatidylinositol bisphosphate phosphatase activity
    		•  3.0061663893933 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
    		•  2.90758198006555 bayes_pls_golite062009
  • phosphoinositide 5-phosphatase activity
    		•  2.90758198006555 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.26056838384313 bayes_pls_golite062009
  • hydrolase activity
    		•  2.21673584332033 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.87742719915012 bayes_pls_golite062009
  • catalytic activity
    		•  1.76511376991978 bayes_pls_golite062009
  • inositol-polyphosphate 5-phosphatase activity
    		•  1.69034937361985 bayes_pls_golite062009
  • inositol trisphosphate phosphatase activity
    		•  1.67310905470506 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.24865228320008 bayes_pls_golite062009
  • nuclease activity
    		•  1.10772848766193 bayes_pls_golite062009
  • binding
    		•  0.762705099992601 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  0.494223168454777 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.469778612465362 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.466524009072462 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.414974033231176 bayes_pls_golite062009
  • exonuclease activity
    		•  0.408287239827419 bayes_pls_golite062009
  • protein binding
    		•  0.224287899263963 bayes_pls_golite062009
  • phosphatase activity
    		•  0.00559251346312178 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0053559034506292 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle