Protein Overview: APA2

General Information:
Name(s) found:	APA2 / YDR530C [SGD]
Description(s) found: Found 29 descriptions. SHOW ALL	Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	325 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	nucleotide metabolic process [IGI][IMP]
Molecular Function:	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity [IDA][IGI][IMP] bis(5'-nucleosyl)-tetraphosphatase activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIEENLKQKI HDKFVAAKKN GHLKVTHAES KKLKDPQTTT QYWVTFAPSL ALKPDANKNS  60
   61 DSKAEDPFAN PDEELVVTED LNGDGEYKLL LNKFPVVPEH SLLVTSEFKD QRSALTPSDL 120
  121 MTAYNVLCSL QGDKDDDVTC ERYLVFYNCG PHSGSSQDHK HLQIMQMPEK FIPFQDVLCN 180
  181 GKDHFLPTFN AEPLQDDKVS FAHFVLPLPE SSDQVDEDLL AMCYVSLMQR ALTFFQDWTN 240
  241 ESPELTKSYN VLLTKKWICV VPRSHAKSGP PLMLNINSTG YCGMILVKDR EKLENLTEDP 300
  301 HLVDKSLLQC GFPNTAGQKP TEYHY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RAD51	APA2	1	Unpublished Fields Lab Data
View Screen	TDH1	APA2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	APA2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..325]	ORFEUS	13.35	Galactose-1-phosphate uridylyltransferase

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
nucleic acid binding	1.74990165024183	bayes_pls_golite062009
binding	1.71599870633602	bayes_pls_golite062009
hydrolase activity	0.690968602046843	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.342529552808262	bayes_pls_golite062009
protein binding	0.315946879872005	bayes_pls_golite062009
catalytic activity	0.096119422680995	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2