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Protein Overview: ITR1

General Information:
Name(s) found: ITR1 / YDR497C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 584 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISSLink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: myo-inositol transport [IMPLink to PubMed article]
    Molecular Function: myo-inositol transmembrane transporter activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIHIPYLTS KTSQSNVGDA VGNADSVEFN SEHDSPSKRG KITLESHEIQ RAPASDDEDR  60
   61 IQIKPVNDED DTSVMITFNQ SLSPFIITLT FVASISGFMF GYDTGYISSA LISIGTDLDH 120
  121 KVLTYGEKEI VTAATSLGAL ITSIFAGTAA DIFGRKRCLM GSNLMFVIGA ILQVSAHTFW 180
  181 QMAVGRLIMG FGVGIGSLIA PLFISEIAPK MIRGRLTVIN SLWLTGGQLV AYGCGAGLNY 240
  241 VNNGWRILVG LSLIPTAVQF TCLCFLPDTP RYYVMKGDLA RATEVLKRSY TDTSEEIIER 300
  301 KVEELVTLNQ SIPGKNVPEK VWNTIKELHT VPSNLRALII GCGLQAIQQF TGWNSLMYFS 360
  361 GTIFETVGFK NSSAVSIIVS GTNFIFTLVA FFSIDKIGRR TILLIGLPGM TMALVVCSIA 420
  421 FHFLGIKFDG AVAVVVSSGF SSWGIVIIVF IIVFAAFYAL GIGTVPWQQS ELFPQNVRGI 480
  481 GTSYATATNW AGSLVIASTF LTMLQNITPA GTFAFFAGLS CLSTIFCYFC YPELSGLELE 540
  541 EVQTILKDGF NIKASKALAK KRKQQVARVH ELKYEPTQEI IEDI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) FPS1 ITR1 ITR2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD51 ITR1 1 Unpublished Fields Lab Data
    View Screen CIT2 ITR1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ITR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..67] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [68..267]
    [320..535]    		 PSI-BLAST 523.0103 No description for 1ja5A_ was found.
    3 View Details [268..319]
    [536..584]    		 PSI-BLAST 523.0103 No description for 1ja5A_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • glycerol transmembrane transporter activity
    		•  7.11654923455995 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  6.7545566917184 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  6.7545566917184 bayes_pls_golite062009
  • glycerol-3-phosphate transmembrane transporter activity
    		•  5.74077413704789 bayes_pls_golite062009
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.54194478414824 bayes_pls_golite062009
  • hexose phosphate transmembrane transporter activity
    		•  3.3746965264994 bayes_pls_golite062009
  • glucose-6-phosphate transmembrane transporter activity
    		•  3.3746965264994 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  2.99050613058546 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  2.99050613058546 bayes_pls_golite062009
  • monosaccharide transmembrane transporter activity
    		•  2.63293544825311 bayes_pls_golite062009
  • carbohydrate transmembrane transporter activity
    		•  2.62141276633776 bayes_pls_golite062009
  • sugar transmembrane transporter activity
    		•  2.47557586092261 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.21266150105753 bayes_pls_golite062009
  • solute:hydrogen symporter activity
    		•  2.10485633822652 bayes_pls_golite062009
  • binding
    		•  1.89539096965643 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.79369588808394 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • sugar binding
    		•  0.285073104957756 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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