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Protein Overview: ARH1

General Information:
Name(s) found: ARH1 / YDR376W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 493 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IMPLink to PubMed article]
    Molecular Function: NADPH-adrenodoxin reductase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFVQIRHIS SQINRKTVSI VGSGPSGFYT AYHLLKKSPI PLNVTIWEKL PVPFGLSRYG  60
   61 VAPDHPEVKN CEETFTTCAE EFSSPTNQKH KFSFVGGITI GKEILLKELL DNQDAVILSY 120
  121 GCTGDRKLNI PGELGTKGVF SSREFVNWYN GHPDFAKDKR FTDFDWSKVS KVGIIGNGNV 180
  181 ALDITRVLIS NQIDEIWENT DISSLALNLL RRAPVKDVKL IARRDFVHSK FTNKELRELW 240
  241 ELEKYGIRGR IDPKFFQKEM FDPSKYDRAF NRRVEMCSEY LKPFNERSKK NYKKAPPPSS 300
  301 GYDKFWELDY LKTPLKINRD DFGAINSLSL CNNRLNEDNS LQPLKDVNNI MTYKVDLLIT 360
  361 SLGYAGVPMP EFSKLSIGFD KDHIANKQGR VLTSSGEIFP HLYASGWIRK GSQGVIASTM 420
  421 QDAFEVGDRV IQDLVVSGAL SLENSIDLSN IKHTTWKDWE RINKKELLRG KKEHKTRSKF 480
  481 LTFEELWNGV EGI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ARH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..124]
    [364..466]
    [482..493]    		 PSI-BLAST 713.616428 Adrenodoxin reductase of mitochondrial p450 systems
    2 View Details [125..363]
    [467..481]    		 PSI-BLAST 713.616428 Adrenodoxin reductase of mitochondrial p450 systems

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • NADPH-adrenodoxin reductase activity
    		•  5.80270482091908 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  4.45434904225178 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.10828870968712 bayes_pls_golite062009
  • antioxidant activity
    		•  1.49429830917872 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.39990343076756 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  1.29733355244701 bayes_pls_golite062009
  • catalytic activity
    		•  1.13824203225664 bayes_pls_golite062009
  • thioredoxin-disulfide reductase activity
    		•  0.844975371289313 bayes_pls_golite062009
  • binding
    		•  0.794954996246594 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  0.68737141906442 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  0.379282693663222 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  0.31095562417378 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  0.0706880697754912 bayes_pls_golite062009
  • protein binding
    		•  0.0171008177759692 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle