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Protein Overview: GGA1

General Information:
Name(s) found: GGA1 / YDR358W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 557 amino acids

    Gene Ontology:
    Cellular Component: trans-Golgi network [IDALink to PubMed article]
    Biological Process: protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway [IMPLink to PubMed article]
    Golgi to endosome transport [IMPLink to PubMed article]
    Golgi to vacuole transport [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: ubiquitin binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQRIELTSE PVRKPRSTES SLLRKIQRAC RSTLPEPDLG LNLDVADYIN SKQGATPREA  60
   61 VLAIEKLVNN GDTQAAVFAL SLLDVLVKNC GYSIHLQISR KEFLNDLVKR FPEQPPLRYS 120
  121 KVQQMILEAI EEWYQTICKH ASYKDDLQYI NDMHKLLKYK GYTFPKVGSE NLAVLRPNDQ 180
  181 LRTPSELQEE QERAQAAKLE ELLRSGKPDD LKEANKLMKI MAGFKDDTKV AVKQAINNEL 240
  241 NKLKRKADLF NEMLTSADEP DLENEAIQEL YGDLKSAQPK FKKLIEEERD DDALVSNLSK 300
  301 FNDLVIQLLK RYKSIKGMKE EELNVPDTNE PAKELNLIDF DDDTTANTPS VTSPSKSLQP 360
  361 FDDLLGDFNK VSLSSPKSPQ ENDTVVDILG DAHSKSSGID LLDFDSQPGE SKTALSAYSN 420
  421 SIVLPNGLLN SSSNSKEITA QSQRHILNQS DHLRIDYELT RESMTKLRLV IFYSNISSDP 480
  481 ITNFALLVAS PKGTTLSLQP QSGNMLQSNS RDGIKQIASV EGISVNLGKP IKLKWKANYC 540
  541 TKGDSKEESG TTSLPTI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) GGA1 GGA2 GYL1 VPS45 VPS52 VTI1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ARF3 GGA1 2 Unpublished Fields Lab Data
    View Screen RRB1 GGA1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GGA1 and CHC1 Huh WK, et al. (2003)
    View Data GGA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] PSI-BLAST 171.134302 Hrs
    2 View Details [94..187] PSI-BLAST 171.134302 Hrs
    3 View Details [188..234]
    [283..409]    		 ORFEUS 7.52 Variant surface glycoprotein (N-terminal domain)
    4 View Details [235..282] ORFEUS 7.52 Variant surface glycoprotein (N-terminal domain)
    5 View Details [410..557] PSI-BLAST 35.39794 Gamma1-adaptin domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.93554535044651 bayes_pls_golite062009
  • transporter activity
    		•  1.4237388137024 bayes_pls_golite062009
  • protein binding
    		•  1.17960228368657 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle