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Protein Overview: IRC3

General Information:
Name(s) found: IRC3 / YDR332W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 689 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSTLATRLS TYSISLILQR IKIIKRCYSA PVLRDYQQDA IDACVNSIRQ GTKRIGVSLA  60
   61 TGGGKTVIFS NLINQLRQNY FKERQGNFKS LILVHRRELA LQATATLKKI FPDLKVHIEM 120
  121 GKYDCDIEDS DVIVASVQTL IRRLHKYDTN SVNLIIIDEA HHSVANSYRS ILDHFKASTA 180
  181 ETKIPVIGFS ATFERADKRA LSMVMDKIVY HRGILEMIDD KWLCEAKFTS VKIEADLSDV 240
  241 KSTADDFQLA PLSSLMNTKE INEVILKTYL HKKQEKSLKS TLLFGVDKAH VQSLHKLFKD 300
  301 NGINTDYVTS DTKQIERDNI IQKFKNGETE VLMNCGIFTE GTDMPNIDCI LLCRPTKSRS 360
  361 LLIQMIGRGL RLHHSKDHCH IIDFIGASSV GVVSAPTLLG IRSDDIEFDD ATVEDLKAIQ 420
  421 GEIIAKQQKI DERLRALFQT DEAAMENVTE RNSVADWIHS ANSVDLTLCS FDSFRNFTQS 480
  481 NNSYPSGKEF DEASEAVKEM ELLMNSQYPW VKFASNAWGL PLKGKNHLRI YKEKSEDKLS 540
  541 MVYHLKMYRQ LPCFITNKYA DYVPKSIIKD ANLWNVMSKV EKIINTLNSD LEGQTMQYQA 600
  601 ISSKYSKWRQ TVPTSKQRDF VFRKLKKVYG ESSKDFIRLS LDDVTTYVNT KMTKGDASNL 660
  661 IFASSLAPVY PLKSLLRILE YQKRRSFIK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) IRC3 JSN1 RBL2 YJL107C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RCY1 IRC3 1 Unpublished Fields Lab Data
    View Screen YLR224W IRC3 1 Unpublished Fields Lab Data
    View Screen CTF13 IRC3 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data IRC3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..410] PSI-BLAST 132.228787 Initiation factor 4a
    2 View Details [411..523] PSI-BLAST 72.228787 Nucleotide excision repair enzyme UvrB
    3 View Details [524..689] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.837538244475264 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.420384345567397 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.411077559082206 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.399864241228259 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.398496265411009 bayes_pls_golite062009
  • catalytic activity
    		•  0.234613562021476 bayes_pls_golite062009
  • hydrolase activity
    		•  0.216831145240405 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  0.837538244475264 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.420384345567397 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.411077559082206 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.399864241228259 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.398496265411009 bayes_pls_golite062009
  • catalytic activity
    		•  0.234613562021476 bayes_pls_golite062009
  • hydrolase activity
    		•  0.216831145240405 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle