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Protein Overview: GPI8

General Information:
Name(s) found: GPI8 / YDR331W [SGD]
Description(s) found:
Found 30 descriptions.
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  • ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 411 amino acids

    Gene Ontology:
    Cellular Component: GPI-anchor transamidase complex [IPILink to PubMed article]
    Biological Process: attachment of GPI anchor to protein [IMPLink to PubMed article]
    Molecular Function: GPI-anchor transamidase activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIAMHLPLL LLYIFLLPLS GANNTDAAHE VIATNTNNWA VLVSTSRFWF NYRHMANVLS  60
   61 MYRTVKRLGI PDSQIILMLS DDVACNSRNL FPGSVFNNKD HAIDLYGDSV EVDYRGYEVT 120
  121 VENFIRLLTD RWTEDHPKSK RLLTDENSNI FIYMTGHGGD DFLKFQDAEE IASEDIADAF 180
  181 QQMYEKKRYN EIFFMIDTCQ ANTMYSKFYS PNILAVGSSE MDESSYSHHS DVEIGVAVID 240
  241 RFTYYCLDFL EQIDKNSTLT LQDLFDSFTF EKIHSHVGVR TDLFDRNPSE VLITDFFANV 300
  301 QNVIPDDSKP LSVSHYHHYK DHIDTAQYEL NNNVLDLALE TYRKNNQSSK IEKKIKDIKS 360
  361 TSVLDVDIDS NECFFTSFKQ SATIILALIV TILWFMLRGN TAKATYDLYT N

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) GAA1 GPI8
    View Details Qiu et al. (2008) GAA1 GAB1 GPI16 GPI17 GPI8 LAS21

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GPI8 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..358] Pfam 197.060481 Peptidase C13 family No confident structure predictions are available.
    2 View Details [359..411] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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