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Protein Overview: PIB1

General Information:
Name(s) found: PIB1 / YDR313C [SGD]
Description(s) found:
Found 26 descriptions.
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  • RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 286 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    late endosome [IDALink to PubMed article]
    Biological Process: protein ubiquitination [IDALink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDALink to PubMed article]
    phosphatidylinositol-3-phosphate binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVIKEDCINN LARWQADEEA HSCFQCKTNF SFLVRRHHCR CCGRIFCSSC TENFVNYNKK  60
   61 RVHALQKKNS DVESPPYRTC NECYDNLLHL NLLVSSTNRD VRLSQTSVPP NALALSAPDS 120
  121 NTDEDAEILE DSVDQSGTAC RSEESSQNEE DHFCPICNSD LTQFPDEEET RKHVEDCIQR 180
  181 AENAQQHTNT SDAADDSVKE SPAFQNRMLV YKISPNTTDN AIKECPICFE NMEPGEKVGR 240
  241 LECLCVFHYK CIKNWFHKRA QMTAAQKGNG HAFVKRNFCP FHDAVF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) EMP70 PIB1
    View Details Ho Y, et al. (2002) PIB1 UBI4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MET18 PIB1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PIB1 and SNF7 Huh WK, et al. (2003)
    View Data PIB1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] PSI-BLAST 77.68867 Eea1; Eea1 homodimerisation domain
    2 View Details [90..159] deduced N/A No confident structure predictions are available.
    3 View Details [160..286] PSI-BLAST 3.522879 STRUCTURE OF THE C3HC4 DOMAIN BY 1H-NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; A NEW STRUCTURAL CLASS OF ZINC-FINGER


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle