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Protein Overview: GLO2

General Information:
Name(s) found: GLO2 / YDR272W [SGD]
Description(s) found:
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  • gi|6320478|ref|NP_010558.1| Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; Glo2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2494851|sp|Q05584.1|GLO2_YEAST RecName: Full=Hydroxyacylglutathione hydrolase, cytoplasmic isozyme; AltName: Full=Glyoxalase II; Short=Glx II [NCBI NR]
  • pir||S70130 hypothetical protein YDR272w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1773012|emb|CAA71335.1| glyoxalase-II [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1230643|gb|AAB64450.1| Glo2p: Glyoxalase-II [Saccharomyces cerevisiae] [NCBI NR]
  • Hydroxyacylglutathione hydrolase, cytoplasmic isozyme OS=Saccharomyces cerevisiae GN=GLO2 PE=1 SV=1 [Swiss-Prot]
  • GLO2 Glyoxalase II (hydroxyacylglutathione hydrolase) [mips]
  • Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate [SGD]
  • GLO2, Chr IV from 1009001-1009825 [yeast_orfs2]
  • Chr IV from 1009001-1009825 [yeastorf3.fasta]
  • (Q05584) Hydroxyacylglutathione hydrolase, cytoplasmic isozyme (EC 3.1.2.6) (Glyoxalase II) (Glx II) [4932.FASTACCERV.txt]
  • GLO2 SGDID:S0002680, Chr IV from 1009002-1009826, Verified ORF [yeastflysequest.fasta]
  • GLO2 SGDID:S0002680, Chr IV from 1009004-1009828, Verified ORF [10112005cervSGD.fasta]
  • Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate [Saccharomyces cerevisiae]gi|1773012|emb|CAA71335.1| glyoxalase-II [Saccharomyces cerevisiae]gi|1230643|gb|AAB64450.1| Glo2p: Glyoxalase-II [Sac [nrdb_11152004_Chlamydomonas]
  • GLO2 SGDID:S000002680, Chr IV from 1009004-1009828, Verified ORF, "Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • GLO2 SGDID:S000002680, Chr IV from 1009006-1009830, Verified ORF, "Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate" [yeast-contam.fasta]
  • GLO2 SGDID:S000002680, Chr IV from 1009007-1009831, Verified ORF, "Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Hydroxyacylglutathione hydrolase, cytoplasmic isozyme (Glyoxalase II) (Glx II) [nr-271106-contam.fasta]
  • glyoxalase-II [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; Glo2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Glo2p: Glyoxalase-II [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Hydroxyacylglutathione hydrolase, cytoplasmic isozyme OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GLO2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • GLO2 SGDID:S000002680, Chr IV from 1009010-1009834, Genome Release 64-1-1, Verified ORF, "Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate" [yeast-030211-contam.fasta]
  • GLO2 SGDID:S000002680, Chr IV from 1009010-1009834, Genome Release 64-2-1, Verified ORF, "Cytoplasmic glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO2 has a paralog, GLO4, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YDR272W SGDID:S000002680, Chr IV from 1009010-1009834, Genome Release 64-1-1, Verified ORF, "Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 274 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: carbohydrate metabolic process [IMPLink to PubMed article]
    methylglyoxal catabolic process to D-lactate [IDALink to PubMed article]
    Molecular Function: hydroxyacylglutathione hydrolase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQVKSIKMRW ESGGVNYCYL LSDSKNKKSW LIDPAEPPEV LPELTEDEKI SVEAIVNTHH  60
   61 HYDHADGNAD ILKYLKEKNP TSKVEVIGGS KDCPKVTIIP ENLKKLHLGD LEITCIRTPC 120
  121 HTRDSICYYV KDPTTDERCI FTGDTLFTAG CGRFFEGTGE EMDIALNNSI LETVGRQNWS 180
  181 KTRVYPGHEY TSDNVKFVRK IYPQVGENKA LDELEQFCSK HEVTAGRFTL KDEVEFNPFM 240
  241 RLEDPKVQKA AGDTNNSWDR AQIMDKLRAM KNRM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GLO2 UTR2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GLO2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] PSI-BLAST 468.09691 Glyoxalase II (hydroxyacylglutathione hydrolase)
    2 View Details [121..190] PSI-BLAST 468.09691 Glyoxalase II (hydroxyacylglutathione hydrolase)
    3 View Details [191..274] PSI-BLAST 468.09691 Glyoxalase II (hydroxyacylglutathione hydrolase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydroxyacylglutathione hydrolase activity
    		•  3.53012507604564 bayes_pls_golite062009
  • catalytic activity
    		•  0.941400907161877 bayes_pls_golite062009
  • binding
    		•  0.900972948435178 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  0.802604883362264 bayes_pls_golite062009
  • hydrolase activity
    		•  0.021392930321391 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle