YRC Public Data Repository - Protein Structure Prediction

Protein:	GLO2
Organism:	Saccharomyces cerevisiae
Length:	274 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLO2.

Description	E-value	Query Range	Subject Range
GLO2 - Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D... GLO2_YEAST - Hydroxyacylglutathione hydrolase, cytoplasmic isozyme OS=Saccharomyces cerevisiae (strain ATCC 20450... gi\|190404782 - gi\|190404782\|gb\|EDV08049.1\| glyoxylase-II [Saccharomyces cerevisiae RM11-1a] gi\|207346513 - gi\|207346513\|gb\|EDZ72989.1\| YDR272Wp-like protein [Saccharomyces cerevisiae AWRI1631]	6.0E-62	[1..274]	[1..274]
gi\|25406895, gi\|... - gi\|8810475\|gb\|AAF80136.1\|AC024174_18 Contains similarity to glyoxalase II isozyme from Arabidopsis t...	3.0E-61	[1..272]	[257..508]
gi\|16209608 - gi\|16209608\|gb\|AAL14249.1\| glyoxalase II [Oryza sativa] gi\|113631906, gi... - gi\|50726249\|dbj\|BAD33825.1\| glyoxalase II [Oryza sativa Japonica Group], gi\|215737215\|dbj\|BAG96144.1... gi\|218202459 - gi\|218202459\|gb\|EEC84886.1\| hypothetical protein OsI_32046 [Oryza sativa Indica Group]	7.0E-60	[1..272]	[83..334]
CG4365-PA - This gene is referred to in FlyBase by the symbol Dmel\CG4365 (CG4365, FBgn0037024). It is a protein... gi\|220954192, gi... - gi\|220954192\|gb\|ACL89639.1\| CG4365-PA [synthetic construct], gi\|220944250\|gb\|ACL84668.1\| CG4365-PA [...	2.0E-59	[1..272]	[47..301]
gi\|123980634, gi... - gi\|157928850\|gb\|ABW03710.1\| hydroxyacylglutathione hydrolase [synthetic construct], gi\|123995455\|gb\|... HAGH - hydroxyacylglutathione hydrolase	3.0E-57	[1..273]	[1..254]
GLO2_MOUSE - Hydroxyacylglutathione hydrolase OS=Mus musculus GN=Hagh PE=2 SV=1	2.0E-56	[1..273]	[1..254]

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Predicted Domain #1

Region A:
Residues: [1-120]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQVKSIKMRW ESGGVNYCYL LSDSKNKKSW LIDPAEPPEV LPELTEDEKI SVEAIVNTHH  60
   61 HYDHADGNAD ILKYLKEKNP TSKVEVIGGS KDCPKVTIIP ENLKKLHLGD LEITCIRTPC 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	468.09691
Match:	1qh3A_
Description:	Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydroxyacylglutathione hydrolase activity	3.53012507604564	bayes_pls_golite062009
catalytic activity	0.941400907161877	bayes_pls_golite062009
binding	0.900972948435178	bayes_pls_golite062009
thiolester hydrolase activity	0.802604883362264	bayes_pls_golite062009
hydrolase activity	0.021392930321391	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [121-190]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HTRDSICYYV KDPTTDERCI FTGDTLFTAG CGRFFEGTGE EMDIALNNSI LETVGRQNWS  60
   61 KTRVYPGHEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	468.09691
Match:	1qh3A_
Description:	Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [191-274]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSDNVKFVRK IYPQVGENKA LDELEQFCSK HEVTAGRFTL KDEVEFNPFM RLEDPKVQKA  60
   61 AGDTNNSWDR AQIMDKLRAM KNRM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	468.09691
Match:	1qh3A_
Description:	Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: