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Protein Overview: HEM1

General Information:
Name(s) found: HEM1 / YDR232W [SGD]
Description(s) found:
Found 29 descriptions.
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  • 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 548 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: heme biosynthetic process [IMPLink to PubMed article]
    regulation of transcription [IMPLink to PubMed article]
    Molecular Function: 5-aminolevulinate synthase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRSIFARFG NSSAAVSTLN RLSTTAAPHA KNGYATATGA GAAAATATAS STHAAAAAAA  60
   61 AANHSTQESG FDYEGLIDSE LQKKRLDKSY RYFNNINRLA KEFPLAHRQR EADKVTVWCS 120
  121 NDYLALSKHP EVLDAMHKTI DKYGCGAGGT RNIAGHNIPT LNLEAELATL HKKEGALVFS 180
  181 SCYVANDAVL SLLGQKMKDL VIFSDELNHA SMIVGIKHAN VKKHIFKHND LNELEQLLQS 240
  241 YPKSVPKLIA FESVYSMAGS VADIEKICDL ADKYGALTFL DEVHAVGLYG PHGAGVAEHC 300
  301 DFESHRASGI ATPKTNDKGG AKTVMDRVDM ITGTLGKSFG SVGGYVAASR KLIDWFRSFA 360
  361 PGFIFTTTLP PSVMAGATAA IRYQRCHIDL RTSQQKHTMY VKKAFHELGI PVIPNPSHIV 420
  421 PVLIGNADLA KQASDILINK HQIYVQAINF PTVARGTERL RITPTPGHTN DLSDILINAV 480
  481 DDVFNELQLP RVRDWESQGG LLGVGESGFV EESNLWTSSQ LSLTNDDLNP NVRDPIVKQL 540
  541 EVSSGIKQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HEM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..66] deduced N/A No confident structure predictions are available.
    2 View Details [67..121]
    [393..548]    		 PSI-BLAST 570.512579 2-amino-3-ketobutyrate CoA ligase
    3 View Details [122..392] PSI-BLAST 570.512579 2-amino-3-ketobutyrate CoA ligase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  3.359406422625 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  3.15163480353521 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • transferase activity
    		•  1.88724762473867 bayes_pls_golite062009
  • N-succinyltransferase activity
    		•  1.81799375593294 bayes_pls_golite062009
  • threonine aldolase activity
    		•  1.80396420390785 bayes_pls_golite062009
  • adenosylmethionine-8-amino-7-oxononanoate transaminase activity
    		•  1.74778109525713 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.63055151623667 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.63055151623667 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.19150094103499 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07873942461292 bayes_pls_golite062009
  • glycine C-acetyltransferase activity
    		•  0.935794708043259 bayes_pls_golite062009
  • DNA binding
    		•  0.886628214497634 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.814403324199462 bayes_pls_golite062009
  • structural molecule activity
    		•  0.754675308623467 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  0.698312655247044 bayes_pls_golite062009
  • binding
    		•  0.661198018681765 bayes_pls_golite062009
  • intramolecular transferase activity, transferring amino groups
    		•  0.659071155545801 bayes_pls_golite062009
  • transcription factor activity
    		•  0.615294010373048 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.15938456446406 bayes_pls_golite062009
  • sulfurtransferase activity
    		•  0.0450490929307473 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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