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Protein Overview: GRX6

General Information:
Name(s) found: GRX6 / YDL010W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX7 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 231 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIPSNKRNAR ILSITTLLLL LVFFVAQNAN FLTVEIKEET SKAFSTNMDN MAGGSSREYA  60
   61 AMPTSTTNKG SSEVDEEINE IKQKVGLQQP IASVDDSLSA IKNDKGSRIT KAFNVQKEYS 120
  121 LILDLSPIII FSKSTCSYSK GMKELLENEY QFIPNYYIIE LDKHGHGEEL QEYIKLVTGR 180
  181 GTVPNLLVNG VSRGGNEEIK KLHTQGKLLE SLQVWSDGKF SVEQREKPSN N

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GRX6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..105] PSI-BLAST 11.39794 Peroxiredoxin 5
    2 View Details [106..231] PSI-BLAST 84.40824 Glutaredoxin (Grx, thioltransferase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antioxidant activity
    		•  3.26520127994042 bayes_pls_golite062009
  • peroxidase activity
    		•  3.04028765378214 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.04028765378214 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.012364779649 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.8187537496904 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • protein disulfide isomerase activity
    		•  1.04609283259723 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing S-S bonds
    		•  1.04609283259723 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting keto- and enol-groups
    		•  0.959318279607901 bayes_pls_golite062009
  • binding
    		•  0.828696005067827 bayes_pls_golite062009
  • signal transducer activity
    		•  0.640027357599919 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.640027357599919 bayes_pls_golite062009
  • hydrolase activity
    		•  0.535462970986225 bayes_pls_golite062009
  • selenium binding
    		•  0.422666385408905 bayes_pls_golite062009
  • protein binding
    		•  0.134341907247724 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.11944067282418 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle