Protein Overview: HCM1

General Information:
Name(s) found:	HCM1 / YCR065W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|14588951\|emb\|CAA42280.2\| transcription factor [Saccharomyces cerevisiae] [NCBI NR] gi\|10383801\|ref\|NP_009991.2\| Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere ma [NCBI NR] HCM1 Transcription factor [mips] Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role [SGD] HCM1, Chr III from 229302-230996 [yeast_orfs2] Chr III from 229302-230996 [yeastorf3.fasta] >CAA42280 (CAA42280) Transcription factor [4932.FASTACCERV.txt] HCM1 SGDID:S0000661, Chr III from 229305-230999, Verified ORF [yeastflysequest.fasta] Forkhead transcription factor involved in cell cycle specific transcription of SPC110, encoding a spindle pole body (SPB) calmodulin binding protein; dosage-dependent suppressor of calmodulin mutants with specific defects in SPB assembly [Saccharomyces ce [nrdb_11152004_Chlamydomonas] HCM1 SGDID:S000000661, Chr III from 229305-230999, Verified ORF, "Forkhead transcription factor involved in cell cycle specific transcription of SPC110, encoding a spindle pole body (SPB) calmodulin binding protein; dosage-dependent suppressor of calmodul [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] HCM1 SGDID:S000000661, Chr III from 229306-231000, Verified ORF, "Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with speci [yeast-contam.fasta] Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role; Hcm1p [Saccha [nr-271106-contam.fasta] transcription factor [Saccharomyces cerevisiae] [nr-271106-contam.fasta] HCM1 SGDID:S000000661, Chr III from 229306-231000, Verified ORF, "Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Forkhead transcription factor HCM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HCM1 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] HCM1 SGDID:S000000661, Chr III from 229310-231004, Genome Release 64-1-1, Verified ORF, "Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role" [yeast-030211-contam.fasta] HCM1 SGDID:S000000661, Chr III from 229310-231004, Genome Release 64-2-1, Verified ORF, "Forkhead transcription factor; drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role; regulates replicative lifespan; ortholog of C. elegans lifespan regulator PHA-4" [20141208_orf_trans.fasta] YCR065W SGDID:S000000661, Chr III from 229310-231004, Genome Release 64-1-1, Verified ORF, "Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	564 amino acids
Gene Ontology:
Cellular Component:	nucleus [IPI]
Biological Process:	spindle pole body organization [IGI] regulation of transcription involved in G1/S-phase of mitotic cell cycle [IPI] telomere maintenance [IMP] regulation of transcription involved in S-phase of mitotic cell cycle [IMP] regulation of transcription from RNA polymerase II promoter [IDA][ISS]
Molecular Function:	DNA binding [IDA][IMP] specific RNA polymerase II transcription factor activity [IDA][IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNEDISIID GHNSFLTEKS TVLLTQAKRT LEDEKEMITP PSSTVRKTMK EVNKRPSHPL  60
   61 SPDHSSPIAP SKAKRQRSDT CARSNGNLTL EEILQSLERR RINGELAKKP PYSYATLICL 120
  121 AILQSQEGKL TLSQIYHWIH VHFPYYKQKD ASWQNSIRHN LSLNDAFIKT EKSCDGKGHF 180
  181 WEVRPGAETK FFKGENRGYE FVKDSLQDIG KYFEIDSTLD ELEQVESGEG NDDLPDEEER 240
  241 EEAGKFPSIE IQLNSSPILR VSQLHHIPQL KTDNSVLNPH ENLESMRNMI ENDVNNIDSL 300
  301 EPPYVMKKYH TSLGLPSLVN AKDHFQAGVK NNNITQANRF NTLPITSAKS PQNFRKYFTS 360
  361 FNSNFEDLSP LRSNVGAGSL LDPLPYSPLK LYDQKNLALM SKPQSQQSYS NSQLPPPPSS 420
  421 HGSDLLKTPK MRHSDGLEKT PSRLISTPKD GNSILRKWQT PSHLFEDLYC SPLFRAIETP 480
  481 IRYITTPGGT LETQISPRKS SAPDVLTSAT NSKFASSGLF GVDVYSVWKR ATEKISDGNN 540
  541 TTDSNQKHHP YHNHPSNDSG NEKN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ADH7 HCM1 OLA1 SNF8 VPS25 VPS36

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	NAF1	HCM1	1	Hazbun TR, et al. (2003)
View Screen	RAD9	HCM1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	HCM1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..102]	deduced	N/A	No confident structure predictions are available.
2	View Details	[103..204]	PSI-BLAST	41.221849	Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
3	View Details	[205..436]	MSA	7.445997	View MSA. No confident structure predictions are available.
4	View Details	[437..564]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2