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Protein Overview: ROT2

General Information:
Name(s) found: ROT2 / YBR229C [SGD]
Description(s) found:
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  • gi|6319706|ref|NP_009788.1| Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; Rot2p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S46105 glucan 1,4-alpha-glucosidase homolog - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|586346|sp|P38138.1|GLU2A_YEAST RecName: Full=Glucosidase 2 subunit alpha; AltName: Full=Glucosidase II subunit alpha; AltName: Full=Alpha-glucosidase II subunit alpha; AltName: Full=Reversal of TOR2 lethality protein 2; Flags: Precursor [NCBI NR]
  • gi|536626|emb|CAA85192.1| ROT2 [Saccharomyces cerevisiae] [NCBI NR]
  • (P38138) Putative family 31 glucosidase in FAT2-PBP2 intergenic region (EC 3.2.1.-) [Swiss-Prot]
  • Glucosidase 2 subunit alpha OS=Saccharomyces cerevisiae GN=ROT2 PE=1 SV=1 [Swiss-Prot]
  • ROT2 Glucosidase II, glycosyl hydrolase catalytic subunit [mips]
  • Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations [SGD]
  • ROT2, Chr II from 676315-679179, reverse complement [yeast_orfs2]
  • Chr II from 676315-679179, reverse complement [yeastorf3.fasta]
  • Chr II from 676314-679178, reverse complement [yeastorf4.fasta]
  • Chr II from 679176-676312, reverse complement [yeastorf5.fasta]
  • ROT2 SGDID:S0000433, Chr II from 679178-676314, reverse complement, Verified ORF [yeastflysequest.fasta]
  • ROT2 SGDID:S0000433, Chr II from 679216-676352, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations [Saccharomyces cerevisiae]gi|536626|emb|CAA85192.1| ROT2 [Saccharomyces cerevisiae]gi|6 [nrdb_11152004_Chlamydomonas]
  • ROT2 SGDID:S000000433, Chr II from 679216-676352, reverse complement, Verified ORF, "Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Glucosidase 2 subunit alpha precursor (Glucosidase II subunit alpha) (Alpha-glucosidase II subunit alpha) (Reversal of TOR2 lethality protein 2) [nr-271106-contam.fasta]
  • ROT2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; Rot2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Glucosidase 2 subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ROT2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ROT2 SGDID:S000000433, Chr II from 679221-676357, Genome Release 64-1-1, reverse complement, Verified ORF, "Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations" [yeast-030211-contam.fasta]
  • ROT2 SGDID:S000000433, Chr II from 679221-676357, Genome Release 64-2-1, reverse complement, Verified ORF, "Glucosidase II catalytic subunit; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations" [20141208_orf_trans.fasta]
  • YBR229C SGDID:S000000433, Chr II from 679221-676357, Genome Release 64-1-1, reverse complement, Verified ORF, "Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 954 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum lumen [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    endoplasmic reticulum [ISSLink to PubMed article]
    Biological Process: fungal-type cell wall biogenesis [IMPLink to PubMed article]
    Molecular Function: alpha-glucosidase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLLKWLVCQ LVFFTAFSHA FTDYLLKKCA QSGFCHRNRV YAENIAKSHH CYYKVDAESI  60
   61 AHDPLENVLH ATIIKTIPRL EGDDIAVQFP FSLSFLQDHS VRFTINEKER MPTNSSGLLI 120
  121 SSQRFNETWK YAFDKKFQEE ANRTSIPQFH FLKQKQTVNS FWSKISSFLS LSNSTADTFH 180
  181 LRNGDVSVEI FAEPFQLKVY WQNALKLIVN EQNFLNIEHH RTKQENFAHV LPEETTFNMF 240
  241 KDNFLYSKHD SMPLGPESVA LDFSFMGSTN VYGIPEHATS LRLMDTSGGK EPYRLFNVDV 300
  301 FEYNIGTSQP MYGSIPFMFS SSSTSIFWVN AADTWVDIKY DTSKNKTMTH WISENGVIDV 360
  361 VMSLGPDIPT IIDKFTDLTG RPFLPPISSI GYHQCRWNYN DEMDVLTVDS QMDAHMIPYD 420
  421 FIWLDLEYTN DKKYFTWKQH SFPNPKRLLS KLKKLGRNLV VLIDPHLKKD YEISDRVINE 480
  481 NVAVKDHNGN DYVGHCWPGN SIWIDTISKY GQKIWKSFFE RFMDLPADLT NLFIWNDMNE 540
  541 PSIFDGPETT APKDLIHDNY IEERSVHNIY GLSVHEATYD AIKSIYSPSD KRPFLLTRAF 600
  601 FAGSQRTAAT WTGDNVANWD YLKISIPMVL SNNIAGMPFI GADIAGFAED PTPELIARWY 660
  661 QAGLWYPFFR AHAHIDTKRR EPYLFNEPLK SIVRDIIQLR YFLLPTLYTM FHKSSVTGFP 720
  721 IMNPMFIEHP EFAELYHIDN QFYWSNSGLL VKPVTEPGQS ETEMVFPPGI FYEFASLHSF 780
  781 INNGTDLIEK NISAPLDKIP LFIEGGHIIT MKDKYRRSSM LMKNDPYVIV IAPDTEGRAV 840
  841 GDLYVDDGET FGYQRGEYVE TQFIFENNTL KNVRSHIPEN LTGIHHNTLR NTNIEKIIIA 900
  901 KNNLQHNITL KDSIKVKKNG EESSLPTRSS YENDNKITIL NLSLDITEDW EVIF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BUD31 GTB1 ROT2
    View Details Krogan NJ, et al. (2006) GTB1 ROT2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TEL1 ROT2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..82] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [83..390] MSA 3.134967 View MSA. No confident structure predictions are available.
    3 View Details [391..586] PSI-BLAST 2.154902 Fungal alpha-amylase; Fungal alpha-amylases
    4 View Details [587..814] MSA 1.130959 View MSA. No confident structure predictions are available.
    5 View Details [815..954] MSA 2.093994 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle