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View Structure Prediction Details

Protein: ROT2
Organism: Saccharomyces cerevisiae
Length: 954 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ROT2.

Description E-value Query
Range
Subject
Range
GLU2A_YEAST - Glucosidase 2 subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ROT2 PE=1 SV...
ROT2 - Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress...
0.0 [1..954] [1..954]
gi|577295 - gi|577295|dbj|BAA07642.1| KIAA0088 [Homo sapiens]
0.0 [7..952] [18..940]
GANAB_PIG - Neutral alpha-glucosidase AB OS=Sus scrofa GN=GANAB PE=1 SV=1
0.0 [7..952] [19..941]
gi|6679891, gi|1... - gi|6679891|ref|NP_032086.1| neutral alpha-glucosidase AB [Mus musculus], gi|2104689|gb|AAC53182.1| a...
0.0 [7..952] [19..963]
PSL5_ARATH - Probable glucan 1,3-alpha-glucosidase OS=Arabidopsis thaliana GN=PSL5 PE=1 SV=1
0.0 [4..952] [4..918]
gi|60473990, gi|... - gi|66825629|ref|XP_646169.1| alpha-glucosidase II [Dictyostelium discoideum AX4], gi|60473990|gb|EAL...
GANAB_DICDI - Neutral alpha-glucosidase AB OS=Dictyostelium discoideum GN=modA PE=3 SV=1
0.0 [1..952] [6..940]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..953] [5..917]

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Predicted Domain #1
Region A:
Residues: [1-82]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLLKWLVCQ LVFFTAFSHA FTDYLLKKCA QSGFCHRNRV YAENIAKSHH CYYKVDAESI  60
   61 AHDPLENVLH ATIIKTIPRL EG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.933 0.026 alpha-glucosidase activity d.45.1 ClpS-like

Predicted Domain #2
Region A:
Residues: [83-390]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDIAVQFPFS LSFLQDHSVR FTINEKERMP TNSSGLLISS QRFNETWKYA FDKKFQEEAN  60
   61 RTSIPQFHFL KQKQTVNSFW SKISSFLSLS NSTADTFHLR NGDVSVEIFA EPFQLKVYWQ 120
  121 NALKLIVNEQ NFLNIEHHRT KQENFAHVLP EETTFNMFKD NFLYSKHDSM PLGPESVALD 180
  181 FSFMGSTNVY GIPEHATSLR LMDTSGGKEP YRLFNVDVFE YNIGTSQPMY GSIPFMFSSS 240
  241 STSIFWVNAA DTWVDIKYDT SKNKTMTHWI SENGVIDVVM SLGPDIPTII DKFTDLTGRP 300
  301 FLPPISSI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [391-586]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYHQCRWNYN DEMDVLTVDS QMDAHMIPYD FIWLDLEYTN DKKYFTWKQH SFPNPKRLLS  60
   61 KLKKLGRNLV VLIDPHLKKD YEISDRVINE NVAVKDHNGN DYVGHCWPGN SIWIDTISKY 120
  121 GQKIWKSFFE RFMDLPADLT NLFIWNDMNE PSIFDGPETT APKDLIHDNY IEERSVHNIY 180
  181 GLSVHEATYD AIKSIY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.154902
Match: 2taaA_
Description: Fungal alpha-amylase; Fungal alpha-amylases
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [587-814]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPSDKRPFLL TRAFFAGSQR TAATWTGDNV ANWDYLKISI PMVLSNNIAG MPFIGADIAG  60
   61 FAEDPTPELI ARWYQAGLWY PFFRAHAHID TKRREPYLFN EPLKSIVRDI IQLRYFLLPT 120
  121 LYTMFHKSSV TGFPIMNPMF IEHPEFAELY HIDNQFYWSN SGLLVKPVTE PGQSETEMVF 180
  181 PPGIFYEFAS LHSFINNGTD LIEKNISAPL DKIPLFIEGG HIITMKDK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [815-954]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRRSSMLMKN DPYVIVIAPD TEGRAVGDLY VDDGETFGYQ RGEYVETQFI FENNTLKNVR  60
   61 SHIPENLTGI HHNTLRNTNI EKIIIAKNNL QHNITLKDSI KVKKNGEESS LPTRSSYEND 120
  121 NKITILNLSL DITEDWEVIF 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle