Protein Overview: PCH2

General Information:
Name(s) found:	PCH2 / YBR186W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|9755327\|ref\|NP_009745.2\| Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; Pch2p [Saccharomyce [NCBI NR] gi\|114152857\|sp\|P38126.2\|PCH2_YEAST RecName: Full=Pachytene checkpoint protein 2 [NCBI NR] Pachytene checkpoint protein 2 OS=Saccharomyces cerevisiae GN=PCH2 PE=1 SV=2 [Swiss-Prot] PCH2 Putative ATPase [mips] Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA [SGD] PCH2, Chr II from 600511-602061,602175-602318 [yeast_orfs2] Chr II from 600511-602061,602175-602318 [yeastorf3.fasta] Chr II from 600510-602060,602174-602317 [yeastorf4.fasta] Chr II from 600508-602058,602172-602315 [yeastorf5.fasta] PCH2 SGDID:S0000390, Chr II from 600510-602060,602174-602317, Verified ORF [yeastflysequest.fasta] PCH2 SGDID:S0000390, Chr II from 600548-602098,602212-602355, Verified ORF [10112005cervSGD.fasta] Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] PCH2 SGDID:S000000390, Chr II from 600548-602098,602212-602355, Verified ORF, "Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhom [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; Pch2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Pachytene checkpoint protein 2 [nr-271106-contam.fasta] PCH2 SGDID:S000000390, Chr II from 600548-602098,602212-602355, Verified ORF, "Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Pachytene checkpoint protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PCH2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PCH2 SGDID:S000000390, Chr II from 600553-602103,602217-602360, Genome Release 64-1-1, Verified ORF, "Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA" [yeast-030211-contam.fasta] PCH2 SGDID:S000000390, Chr II from 600553-602103,602217-602360, Genome Release 64-2-1, Verified ORF, "Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation" [20141208_orf_trans.fasta] YBR186W SGDID:S000000390, Chr II from 600553-602103,602217-602360, Genome Release 64-1-1, Verified ORF, "Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	564 amino acids
Gene Ontology:
Cellular Component:	nucleolus [TAS]
Biological Process:	regulation of meiosis [TAS]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYIVDLQVR GSSLRVIKCM FREDEQISSL HSGSDSKQNS NKKLGEFLNL LKAVVKRKLE  60
   61 SFPKDRLKTS IITGQELMRE GQGSIEIKDP PTEAQQHLIR SLAKVLLHQF SSINGKVNTV 120
  121 NEGQDNLFLS LFVKKISIEQ QSTSHVSIKL NFHEKINLGQ HIDSILDSEE TNESDTYHMG 180
  181 SVDEFIIYPF CCLEEQDELK NGSILSTEFD KIDLELDEDD GFEGETLNNC INSVGNFDIP 240
  241 LSKQTLNLVN ISYLPGTTFE GQWESLYFGN NIKERLYSYA TISLKIARFK QTGDSNQEDI 300
  301 TTLITNNKLL LVHGPPGTGK TTLCKALCQK LSVRREFSDG SDTIDTNYKG IIIELSCARI 360
  361 FSKWFGESSK NISIVFKDIE ELLKVNEGRG IFICLLIDEV EAIASSRTNL SSRNESTDGI 420
  421 RVVNTLLTQL DRLKKYHNFL ALATSNLLDS LDDAFVDRAD GVFYVGNPTA EGILHILKVC 480
  481 IEEMITSGII LFHARSTGVK FFNKYQDILR KIAIKCSTVD ISGRTIRKLP LMCLSEYFRT 540
  541 FPVDDDEFVL ALAMSARKLS AARK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		GRE3 PCH2 PMC1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..564]	PSI-BLAST	78.09691	VCP/p97

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: PCH2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: