Protein Overview: SLI15

General Information:
Name(s) found:	SLI15 / YBR156C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6319632\|ref\|NP_009714.1\| Subunit of the Ipl1p-Sli15p-Bir1p complex that regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; regulates the activity and localization of the Ipl1p a [NCBI NR] pir\|\|S46027 hypothetical protein YBR156c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|586296\|sp\|P38283.1\|SLI15_YEAST RecName: Full=Inner centromere protein-related protein SLI15; Short=INCENP-related protein SLI15 [NCBI NR] gi\|536488\|emb\|CAA85115.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] (P38283) Hypothetical 79.2 kDa protein in CNS1-CDC28 intergenic region [Swiss-Prot] Inner centromere protein-related protein SLI15 OS=Saccharomyces cerevisiae GN=SLI15 PE=1 SV=1 [Swiss-Prot] SLI15 Mitotic spindle protein involved in chromosome segregation [mips] Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly [SGD] SLI15, Chr II from 551062-553158, reverse complement [yeast_orfs2] Chr II from 551062-553158, reverse complement [yeastorf3.fasta] Chr II from 551061-553157, reverse complement [yeastorf4.fasta] Chr II from 553155-551059, reverse complement [yeastorf5.fasta] SLI15 SGDID:S0000360, Chr II from 553156-551060, reverse complement, Verified ORF [yeastflysequest.fasta] SLI15 SGDID:S0000360, Chr II from 553194-551098, reverse complement, Verified ORF [10112005cervSGD.fasta] Mitotic spindle protein involved in chromosome segregation. [Saccharomyces cerevisiae]gi\|536488\|emb\|CAA85115.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|626528\|pir\|\|S46027 hypothetical protein YBR156c - yeast (Saccharomyces cerevisiae)gi\|58 [nrdb_11152004_Chlamydomonas] SLI15 SGDID:S000000360, Chr II from 553194-551098, reverse complement, Verified ORF, "Subunit of the Ipl1p-Sli15p-Bir1p complex that regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassemb [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] SLI15 SGDID:S000000360, Chr II from 553194-551098, reverse complement, Verified ORF, "Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle te [yeast-200209-contam.fasta] Inner centromere protein-related protein SLI15 (INCENP-related protein SLI15) [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Subunit of the Ipl1p-Sli15p-Bir1p complex that regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; regulates the activity and localization of the Ipl1p aurora kinase; Sli15p [Saccha [nr-271106-contam.fasta] SLI15 SGDID:S000000360, Chr II from 553194-551098, reverse complement, Verified ORF, "Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly" [yeast-bovrabprots.fasta] SLI15 SGDID:S000000360, Chr II from 553194-551098, reverse complement, Verified ORF, "Subunit of the Ipl1p-Sli15p-Bir1p complex that regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; regulates the activity and localization of the Ipl1p aurora kinase" [yeast-contam_custom.fasta] [chemostatdb.fasta] Inner centromere protein-related protein SLI15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SLI15 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SLI15 SGDID:S000000360, Chr II from 553200-551104, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly" [yeast-030211-contam.fasta] SLI15 SGDID:S000000360, Chr II from 553200-551104, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of the conserved chromosomal passenger complex (CPC); complex regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; other complex members are Ipl1p, Bir1p, and Nbl1p" [20141208_orf_trans.fasta] TR6520\|c0_g1_i1\|g.4613 ORF TR6520\|c0_g1_i1\|g.4613 TR6520\|c0_g1_i1\|m.4613 type:complete len:699 (+) TR6520\|c0_g1_i1:113-2209(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YBR156C SGDID:S000000360, Chr II from 553200-551104, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_5088\|g.3016 ORF ID=asmbl_5088\|g.3016 ID=asmbl_5088\|m.3016 type:complete len:699 (+) ID=asmbl_5088:120-2216(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	698 amino acids
Gene Ontology:
Cellular Component:	spindle microtubule [IDA] spindle midzone [IDA] kinetochore microtubule [IDA]
Biological Process:	telomere maintenance [IMP] chromosome segregation [TAS] protein amino acid phosphorylation [IMP][IPI]
Molecular Function:	protein kinase activator activity [IMP][IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDWAIKAARK KTQRKPGSTR SIIETLDDLN NLTTDAHSEI NQRLYESSEW LRNNVYMNTL  60
   61 KYEDKKMEES LISPENTHNK MDVEFPKMKG EYELSNSQND AAKDVTKTPR NGLHNDKSIT 120
  121 PKSLRRKEVT EGMNRFSIHD TNKSPVEPLN SVKVDANESE KSSPWSPYKV EKVLRESSKT 180
  181 SESPINTKRF DNQTWAAKEE MENEPILQAL KKAESVKVKP PPNSGIARSQ RRSNMFVPLP 240
  241 NKDPLIIQHI PPTKSSGSIP KVRTVKESPI AFKKKSTINS PAIRAVENSD TAGSTKASSV 300
  301 FDRLSSIPTK SFENKISRGN VGHKYSSSSI DLTGSPMKKV SQKFKSINST DTDMQEALRD 360
  361 IFSVKNKITK NNSPKGKNSR KSSIPRFDKT SLKLTTHKKL AIIAEQKKKS KHSSDVHKTG 420
  421 SRPHSISPTK ISVDSSSPSK EVKNYYQSPV RGYLRPTKAS ISPNKNKNLT TSQTPHRLKI 480
  481 KEKTLRKLSP NIADISKPES RKSKNYRLTN LQLLPPAEAE RDDLKKKFDK RLSGIMRSQQ 540
  541 EHHRRKQEKQ KRMSHLEQDL KKQTSFSNDY KDIRLKESLA PFDNHVRDTI NKNTAFSTDN 600
  601 ILATINTVDH REIIGNVTPK IASVNDSLPE INTDSEDEAS VTLAAWAKSP YLQEQLIRQQ 660
  661 DINPQTIFGP IPPLHTDEIF PNPRLNRLKP RQIVPKRS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		BIR1 SLI15

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	IPL1	No Comments	Cheeseman IM, et al. (2002)
View Run	SLI15	No Comments	Cheeseman IM, et al. (2002)
View Run	BIR1	No Comments	Widlund PO, et al. (2005)
View Run	BIR1	No Comments	Widlund PO, et al. (2005)
View Run	BIR1	No Comments	Widlund PO, et al. (2005)
View Run	BIR1	sample bir 1 from feb 2005	Sandall S, et all (2006)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#02 Alpha Factor Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	SLI15	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..175]	deduced	N/A	No confident structure predictions are available.
2	View Details	[176..631]	MSA	16.253995	View MSA. No confident structure predictions are available.
3	View Details	[632..698]	deduced	N/A	No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: SLI15

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: