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Protein Overview: CYC8

General Information:
Name(s) found: CYC8 / YBR112C [SGD]
Description(s) found:
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  • gi|6319589|ref|NP_009670.1| General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; Cyc8p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|536450|emb|CAA85069.1| CYC8 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|476068|emb|CAA55615.1| glucose repression mediator protein [Saccharomyces cerevisiae] [NCBI NR]
  • gi|3550|emb|CAA46973.1| nuclear phosphoprotein [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S25365 CYC8 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • CYC8 General repressor of transcription [mips]
  • General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+] [SGD]
  • CYC8, Chr II from 462828-465728, reverse complement [yeast_orfs2]
  • Chr II from 462828-465728, reverse complement [yeastorf3.fasta]
  • Chr II from 462827-465727, reverse complement [yeastorf4.fasta]
  • Chr II from 465725-462825, reverse complement [yeastorf5.fasta]
  • CYC8 SGDID:S0000316, Chr II from 465726-462826, reverse complement, Verified ORF [yeastflysequest.fasta]
  • CYC8 SGDID:S0000316, Chr II from 465764-462864, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Cyc8p [Saccharomyces cerevisiae]gi|3550|emb|CAA46973.1| nuclear phosphoprotein [Saccharomyces cerevisiae]gi|476068|emb|CAA55615.1| glucose repression mediator protein [Saccharomyces cerevisiae]gi|536450|emb|CAA85069.1| CYC8 [Saccharomyces cerevisiae]g [nrdb_11152004_Chlamydomonas]
  • CYC8 SGDID:S000000316, Chr II from 465764-462864, reverse complement, Verified ORF, "General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes t [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • nuclear phosphoprotein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; Cyc8p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • glucose repression mediator protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • CYC8 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • CYC8 SGDID:S000000316, Chr II from 465764-462864, reverse complement, Verified ORF, "General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters" [yeast-bovrabprots.fasta]
  • CYC8 SGDID:S000000316, Chr II from 465764-462864, reverse complement, Verified ORF, "General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]" [scerevisihumanrev.fasta]
  • [chemostatdb.fasta]
  • General transcriptional corepressor CYC8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYC8 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • CYC8 SGDID:S000000316, Chr II from 465770-462870, Genome Release 64-1-1, reverse complement, Verified ORF, "General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]" [yeast-030211-contam.fasta]
  • CYC8 SGDID:S000000316, Chr II from 465770-462870, Genome Release 64-2-1, reverse complement, Verified ORF, "General transcriptional co-repressor; acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]" [20141208_orf_trans.fasta]
  • YBR112C SGDID:S000000316, Chr II from 465770-462870, Genome Release 64-1-1, reverse complement, Verified ORF, "General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 966 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: chromatin remodeling [IMPLink to PubMed article]
    negative regulation of transcription [IDALink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    nucleosome positioning [IDALink to PubMed article]
    Molecular Function: transcription coactivator activity [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    general transcriptional repressor activity [IDALink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPGGEQTIM EQPAQQQQQQ QQQQQQQQQQ AAVPQQPLDP LTQSTAETWL SIASLAETLG  60
   61 DGDRAAMAYD ATLQFNPSSA KALTSLAHLY RSRDMFQRAA ELYERALLVN PELSDVWATL 120
  121 GHCYLMLDDL QRAYNAYQQA LYHLSNPNVP KLWHGIGILY DRYGSLDYAE EAFAKVLELD 180
  181 PHFEKANEIY FRLGIIYKHQ GKWSQALECF RYILPQPPAP LQEWDIWFQL GSVLESMGEW 240
  241 QGAKEAYEHV LAQNQHHAKV LQQLGCLYGM SNVQFYDPQK ALDYLLKSLE ADPSDATTWY 300
  301 HLGRVHMIRT DYTAAYDAFQ QAVNRDSRNP IFWCSIGVLY YQISQYRDAL DAYTRAIRLN 360
  361 PYISEVWYDL GTLYETCNNQ LSDALDAYKQ AARLDVNNVH IRERLEALTK QLENPGNINK 420
  421 SNGAPTNASP APPPVILQPT LQPNDQGNPL NTRISAQSAN ATASMVQQQH PAQQTPINSS 480
  481 ATMYSNGASP QLQAQAQAQA QAQAQAQAQA QAQAQAQAQA QAQAQAQAQA QAQAQAHAQA 540
  541 QAQAQAQAQA QAQAQAQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQLQP LPRQQLQQKG 600
  601 VSVQMLNPQQ GQPYITQPTV IQAHQLQPFS TQAMEHPQSS QLPPQQQQLQ SVQHPQQLQG 660
  661 QPQAQAPQPL IQHNVEQNVL PQKRYMEGAI HTLVDAAVSS STHTENNTKS PRQPTHAIPT 720
  721 QAPATGITNA EPQVKKQKLN SPNSNINKLV NTATSIEENA KSEVSNQSPA VVESNTNNTS 780
  781 QEEKPVKANS IPSVIGAQEP PQEASPAEEA TKAASVSPST KPLNTEPESS SVQPTVSSES 840
  841 STTKANDQST AETIELSTAT VPAEASPVED EVRQHSKEEN GTTEASAPST EEAEPAASRD 900
  901 AEKQQDETAA TTITVIKPTL ETMETVKEEA KMREEEQTSQ EKSPQENTLP RENVVRQVEE 960
  961 DENYDD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CYC8 DNF2
    View Details (MIPS) Mewes HW, et al. (2004) CYC8 TUP1
    View Details Krogan NJ, et al. (2006) CYC8 SEC16 UBP14
    View Details Ho Y, et al. (2002) CLU1 CYC8 ECM10 SPH1 SSY5 TUP1
    View Details Qiu et al. (2008) CYC8 TUP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CYC8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94] PSI-BLAST 31.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    2 View Details [95..164] PSI-BLAST 31.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    3 View Details [165..274] PSI-BLAST 31.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    4 View Details [275..443] PSI-BLAST 6.522879 Protein farnesyltransferase alpha-subunit
    5 View Details [444..509] PSI-BLAST 6.522879 Protein farnesyltransferase alpha-subunit
    6 View Details [510..588] ab initio 14.11 No description for 1m2vB was found.
    7 View Details [589..834] ab initio 10.21 No description for 1jv2B was found.
    8 View Details [835..892] ab initio 10.21 No description for 1jv2B was found.
    9 View Details [893..966] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle