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Protein Overview: FLR1

General Information:
Name(s) found: FLR1 / YBR008C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 548 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IDALink to PubMed article]
    Biological Process: response to toxin [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: fluconazole transporter activity [ISS]
    drug transmembrane transporter activity [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVYTSTYRHT IVVDLLEYLG IVSNLETLQS AREDETRKPE NTDKKECKPD YDIECGPNRS  60
   61 CSESSTDSDS SGSQIEKNDP FRVDWNGPSD PENPQNWPLL KKSLVVFQIM LLTCVTYMGS 120
  121 SIYTPGQEYI QEEFHVGHVV ATLNLSLYVL GYGLGPIIFS PLSETARYGR LNLYMVTLFF 180
  181 FMIFQVGCAT VHNIGGLIVM RFISGILCSP SLATGGGTVA DIISPEMVPL VLGMWSAGAV 240
  241 AAPVLAPLLG AAMVDAKNWR FIFWLLMWLS AATFILLAFF FPETQHHNIL YRRALKLRKE 300
  301 TGDDRYYTEQ DKLDREVDAR TFLINTLYRP LKMIIKEPAI LAFDLYIAVA YGCFYLFFEA 360
  361 FPIVFVGIYH FSLVEVGLAY MGFCVGCVLA YGLFGILNMR IIVPRFRNGT FTPEAFLIVA 420
  421 MCVCWCLPLS LFLFGWTARV HWILPVISEV FFVLAVFNIF QATFAYLATC YPKYVASVFA 480
  481 GNGFCRASFA CAFPLFGRAM YDNLATKNYP VAWGSSLVGF LTLGLAIIPF ILYKYGPSLR 540
  541 TRSSYTEE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) FLR1 QDR3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data FLR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..77] deduced N/A No confident structure predictions are available.
    2 View Details [78..548] PSI-BLAST 11.69897 No description for 1lviA_ was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle