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Protein Overview: ALS2_RAT

General Information:
Name(s) found: ALS2_RAT [Swiss-Prot]
Description(s) found:
Found 20 descriptions.
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  • Alsin OS=Rattus norvegicus GN=Als2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 1651 amino acids

    Gene Ontology:
    Cellular Component: postsynaptic density [UNKNOWN][IEA]
    synaptosome [IDA]
    microsome [IDA]
    neuronal cell body [IDA]
    protein complex [UNKNOWN][ISS]
    vesicular fraction [UNKNOWN][ISS]
    intracellular [IEA]
    growth cone [IDA]
    dendrite [UNKNOWN][IDA][ISS]
    early endosome [UNKNOWN][ISS]
    centrosome [UNKNOWN][IEA]
    cytoplasm [UNKNOWN][IDA]
    membrane [IDA]
    dendritic spine [UNKNOWN][IEA]
    ruffle [IEA]
    cytosol [UNKNOWN][ISS]
    axon [IDA]
    lamellipodium [IEA]
    Biological Process: Rac protein signal transduction [IDA]
    regulation of Rho protein signal transduction [IEA]
    endosome organization [UNKNOWN][IEA]
    protein localization [UNKNOWN][IEA]
    neuron projection morphogenesis [UNKNOWN][ISS]
    receptor recycling [UNKNOWN][IEA]
    behavioral fear response [UNKNOWN][IEA]
    neuromuscular junction development [UNKNOWN][IEA]
    response to oxidative stress [UNKNOWN][IEA]
    locomotory behavior [UNKNOWN][IEA]
    cell death [IMP]
    regulation of endosome size [UNKNOWN][ISS]
    vesicle organization [UNKNOWN][IEA]
    in utero embryonic development [IEP]
    positive regulation of protein kinase activity [UNKNOWN][ISS]
    axonogenesis [IMP]
    endosome transport [UNKNOWN][IEA]
    positive regulation of Rac GTPase activity [UNKNOWN][ISS]
    regulation of Rab GTPase activity [UNKNOWN][IEA]
    synaptic transmission, glutamatergic [UNKNOWN][IEA]
    Molecular Function: protein binding [UNKNOWN][IEA]
    protein homodimerization activity [UNKNOWN][ISS]
    protein serine/threonine kinase activator activity [UNKNOWN][ISS]
    guanyl-nucleotide exchange factor activity [UNKNOWN][ISS]
    Rab guanyl-nucleotide exchange factor activity [UNKNOWN][ISS]
    Rab GTPase binding [UNKNOWN][ISS]
    molecular_function [ND]
    Rac guanyl-nucleotide exchange factor activity [UNKNOWN][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSKKKSSAE AEGSKERGLV HVWQAGSFSL TPERLPGWGG KTVLQAALGV KHGVLLTEDG  60
   61 EVYSFGTLPW KSEAAEICPS SPLLESALVG HHVVTVATGS FHSGAVTESG VVYMWGENAA 120
  121 GQCAVANQQY VSEPSPVSIS DSETSPLLAV RILQLACGEE HTLALSISRE IWAWGTGCQL 180
  181 GLITTTFPVT KPQKVEHLAG RVVLQVACGA FHSLALVQCL PPQDLKPVPE RCNQCSQLLI 240
  241 TMTDKEDHVI ISDSHCCPLG VTLSESQAEK HASTVTSPHP ETLDGQGEVF ENTVAEAELN 300
  301 MGSDQTTSGS AISAQQNIVG MAEVSSARTA PSYPDTQTVT AYLQKLSEHS VKENHEREEK 360
  361 LPQVQPLVEE AVPDLHSPPT TSTSALNSLV VSCASAVGVR VAATYEAGAL SLKKVMNFYS 420
  421 TAPCEPGAPS GTASTGPESL KDLREEQVKQ ESLQGKKSSS LMDIREEESE GGSRRLSLPG 480
  481 LLSQVSPRLL RKAARVKTRT VVLTPTYSGE ADALLPSLRT EVWTWGKGKE GQLGHGDVLP 540
  541 RLQPLCVKCL DGKEVIHLEA GGSHSLALTA KSQVYSWGSN TFGQLGHSEF PTTVPRLSKV 600
  601 SSESGVWSVA AGHGYSLFLV DTEDFQPGLY YSGRQDRAEG DTLPENPSGT TTPVLLSCSK 660
  661 LGYISRVTAG KDSYLALVDK NIMGYIASLH ELATTERRFY SKLSEIKSQI LRPLLSLEHL 720
  721 GTVTTVQLLQ EVASRFSKLC YLIGQHGASL SSYLQGMKEA RNLVIMKHSS LFLDSYTEYC 780
  781 TSVSNFLVMG GSQLLAKPAI DFLNKNQELL QDLSEVNDEN TQLMEILNAL FFLPIRRLHN 840
  841 YAKVLLKLAT CFEVTSPEYQ KLQDSSSCYE SLALHLGKKR KEAEYTLSFW KTFPGKMTDS 900
  901 LRKPERRLLC ESSNRALSLQ HAGRFSVNWF ILFNDALVHA QFSTHHVFPL ATLWAEPLSE 960
  961 ETGGVNGLKI TTPEEQFTLI SSTPQEKTKW LRAISQAVDQ ALRGTSDFPL YGGSSTVQRQ1020
 1021 EPPISRSAKY TFYKDTRLKD ATYDGRWLSG KPHGRGVLKW PDGKVYSGTF RNGLEDGYGE1080
 1081 YRIPNKALNK EDHYVGHWKE GKMCGQGVYS YASGEVFEGC FQDNMRHGHG LLRSGKLTSS1140
 1141 SPSMFIGQWV MDKKAGYGVF DDITRGEKYM GMWQDDACQG NGVVVTQFGL YYEGNFHLNK1200
 1201 MMGNGVLLSE DDTIYEGEFS DDWTLCGKGT LTMPNGDYIE GYFSGEWGSG IKITGTYFKP1260
 1261 SLYESDKDRP KAFRKLGNLA VAADEKWRAV FDECWRQLGC ESPGQGEVWK AWDNIAVALT1320
 1321 TNRRQHKDSP EILSRSQTQT LESLEYIPQH VGAFSVEKYD DIKKYLIKAC DTPLHPLGRL1380
 1381 VETLVAVYRM TYVGVGANRR LLQEAVKEIK SYLKRIFQLV RFLFPELPEE GSTVPLSAPL1440
 1441 PTGRRSFCTG KSDSRSESPE PGYVVTSSGL LLPVLLPRLY PPLFMLYALD NDREEDIYWE1500
 1501 CVLRLNKQPD IALLGFLGVQ RKFWPATLSI LGESKKVLPS TKDACFASAV ECLQQISTTF1560
 1561 TPSDKLKVIQ QTFEEISQSV LASLQEDFLW SMDDLFPVFL YVVLRARIRN LGSEVHLIED1620
 1621 LMDPYLQHGE QGIMFTTLKA CYYQIQREKL N

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle