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Protein Overview: pan-PH

General Information:
Name(s) found: pan-PH / FBpp0099631 [FlyBase]
Description(s) found:
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  • gi|62473076|ref|NP_001014685.1| pangolin, isoform H [Drosophila melanogaster] [NCBI NR]
  • gi|61677940|gb|AAX52517.1| pangolin, isoform H [Drosophila melanogaster] [NCBI NR]
  • The gene pangolin is referred to in FlyBase by the symbol Dmel\pan (CG34403, FBgn0085432). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:89956..129430. It has the cytological map location 102A3-102A4. There is experimental evidence that it has the molecular function</span>: specific transcriptional repressor activity. There is experimental evidence that it is involved in the biological process</span>: regulation of Wnt receptor signaling pathway; spiracle morphogenesis, open tracheal system; embryonic pattern specification; regulation of hemocyte differentiation; imaginal disc-derived wing morphogenesis; positive regulation of transcription; salivary gland morphogenesis. 44 alleles are reported. The phenotypes of these alleles are annotated with 38 unique terms, many of which group under: organ system; adult segment; late extended germ band embryo; thoracic segment; muscle founder cell; embryonic/larval tracheal system; peripheral nervous system; adult mesothoracic segment; spiracle; cuticle. It has 10 annotated transcripts and 10 annotated polypeptides. [FlyBase]
  • type=protein; loc=4:join(93056..93220,93443..93488,95694..95791,103264..103372,106338..106425,106479..106559,107643..107792,115049..115241,118448..118601,120032..120101,128029..129118); ID=FBpp0099631; name=pan-PH; parent=FBgn0085432,FBtr0100245; dbxref=F [fly-100309-contam.fasta]
  • CG17964-PH, isoform H [Drosophila melanogaster] [nr-271106-contam.fasta]
  • pangolin CG17964-PH, isoform H [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=4:join(93056..93220,93443..93488,95694..95791,103264..103372,106338..106425,106479..106559,107643..107792,115049..115241,118448..118601,120032..120101,128029..129118); ID=FBpp0099631; name=pan-PH; parent=FBgn0085432,FBtr0100245; dbxref=FlyBase:FBpp0099631,GB_protein:AAX52517.1,FlyBase_Annotation_IDs:CG34403-PH,FlyBase_Annotation_IDs:CG17964-PH,REFSEQ:NP_001014685,GB_protein:AAX52517; MD5=cd21b3205a61bfa4b50602c511689707; length=747; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=4:join(93056..93220,93443..93488,95694..95791,103264..103372,106338..106425,106479..106559,107643..107792,115049..115241,118448..118601,120032..120101,128029..129118); ID=FBpp0099631; name=pan-PH; parent=FBgn0085432,FBtr0100245; dbxref=FlyBase:FBpp0099631,GB_protein:AAX52517.1,FlyBase_Annotation_IDs:CG34403-PH,FlyBase_Annotation_IDs:CG17964-PH,REFSEQ:NP_001014685,GB_protein:AAX52517; MD5=cd21b3205a61bfa4b50602c511689707; length=747; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Isoform H of Protein pangolin, isoforms A/H/I OS=Drosophila melanogaster GN=pan [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=4:join(93056..93220,93443..93488,95694..95791,103264..103372,106338..106425,106479..106559,107643..107792,115049..115241,118448..118601,120032..120101,128029..129118); ID=FBpp0099631; name=pan-PH; parent=FBgn0085432,FBtr0100245; dbxref=FlyBase:FBpp0099631,GB_protein:AAX52517.1,FlyBase_Annotation_IDs:CG34403-PH,FlyBase_Annotation_IDs:CG17964-PH,REFSEQ:NP_001014685,GB_protein:AAX52517,FlyMine:FBpp0099631,modMine:FBpp0099631; MD5=cd21b3205a61bfa4b50602c511689707; length=747; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=4:join(72430..72594,72817..72862,75068..75165,82638..82746,85712..85799,85853..85933,87017..87166,94423..94615,97822..97975,99406..99475,107403..108492); ID=FBpp0099631; name=pan-PH; parent=FBgn0085432,FBtr0100245; dbxref=FlyBase:FBpp0099631,GB_protein:AAX52517.1,FlyBase_Annotation_IDs:CG34403-PH,FlyBase_Annotation_IDs:CG17964-PH,REFSEQ:NP_001014685,GB_protein:AAX52517,FlyMine:FBpp0099631,modMine:FBpp0099631; MD5=cd21b3205a61bfa4b50602c511689707; length=747; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=4:join(72430..72594,72817..72862,75068..75165,82638..82746,85712..85799,85853..85933,87017..87166,94423..94615,97822..97975,99406..99475,107403..108492); ID=FBpp0099631; name=pan-PH; parent=FBgn0085432,FBtr0100245; dbxref=FlyBase:FBpp0099631,GB_protein:AAX52517.1,FlyBase_Annotation_IDs:CG34403-PH,FlyBase_Annotation_IDs:CG17964-PH,REFSEQ:NP_001014685,GB_protein:AAX52517,FlyMine:FBpp0099631,modMine:FBpp0099631; MD5=cd21b3205a61bfa4b50602c511689707; length=747; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q8IMA8, Isoform H of Protein pangolin, isoforms A/H/I/S OS=Drosophila melanogaster GN=pan [DROME.fasta.20160308]
  • FBpp0099631 type=protein; loc=4:join(72430..72594,72817..72862,75068..75165,82638..82746,85712..85799,85853..85933,87017..87166,94423..94615,97822..97975,99406..99475,107403..108492); ID=FBpp0099631; name=pan-PH; parent=FBgn0085432,FBtr0100245; dbxref=FlyBase:FBpp0099631,GB_protein:AAX52517.1,FlyBase_Annotation_IDs:CG34403-PH,FlyBase_Annotation_IDs:CG17964-PH,REFSEQ:NP_001014685,GB_protein:AAX52517,FlyMine:FBpp0099631,modMine:FBpp0099631; MD5=cd21b3205a61bfa4b50602c511689707; length=747; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=4:join(72430..72594,72817..72862,75068..75165,82638..82746,85712..85799,85853..85933,87017..87166,94423..94615,97822..97975,99406..99475,107403..108492); ID=FBpp0099631; name=pan-PH; parent=FBgn0085432,FBtr0100245; dbxref=FlyBase:FBpp0099631,GB_protein:AAX52517.1,FlyBase_Annotation_IDs:CG34403-PH,FlyBase_Annotation_IDs:CG17964-PH,REFSEQ:NP_001014685,GB_protein:AAX52517,FlyMine:FBpp0099631,modMine:FBpp0099631; MD5=cd21b3205a61bfa4b50602c511689707; length=747; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 747 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPHTHSRHGS SGDDLCSTDE VKIFKDEGDR EDEKISSENL LVEEKSSLID LTESEEKGHK  60
   61 ISRPDHSPVF NKLDTHAPSF NMGYLVSPYS YANGSPSGLP VTMANKIGLP PFFCHNADPL 120
  121 STPPPAHCGI PPYQLDPKMG LTRPALYPFA GGQYPYPMLS SDMSQVASWH TPSVYSASSF 180
  181 RTPYPSSLPI NTTLASDFPF RFSPSLLPSV HATSHHVINA HSAIVGVSSK QECGVQDPTT 240
  241 NNRYPRNLEA KHTSNAQSNE SKETTNDKKK PHIKKPLNAF MLYMKEMRAK VVAECTLKES 300
  301 AAINQILGRR WHALGREEQA KYYELARRER QLHMQMYPDW SSRTNASRGK KRKRKQDTND 360
  361 GGNNMKKCRA RFGLDQQSQW CKPCRRKKKC IRYMEALNGN GPAEDGSCFD EHGSQLSDDD 420
  421 EDDYDDDKLG GSCGSADETN KIEDEDSESL NQSMPSPGCL SGLSSLQSPS TTMSLASPLN 480
  481 MNANSATNVI FPASSNALLI VGADQPTAQQ RPTLVSTSGS SSGSTSSIST TPNTSSTVSP 540
  541 VTCMTGPCLG SSQERAMMLG NRFSHLGMGL SPPVVSTSTS KSEPFFKPHP TVCNNPIFAL 600
  601 PSIGNCSLNI SSMPNTSRNP IGANPRDINN PLSINQLTKR REYKNVELIE ASESKTIVAH 660
  661 AATSIIQHVA VNGYHANHSL LNSNLGHLHH QLNNRTENPN RSEQTMLSVS NHSVNSSECH 720
  721 KESDSQAIVS SNPPNAGSSD NGVISVS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..192] Pfam 76.130768 No description for PF08347.2 was found. No confident structure predictions are available.
    2 View Details [193..259] deduced N/A No confident structure predictions are available.
    3 View Details [260..372] PSI-BLAST 13.522879 Lymphoid enhancer-binding factor, LEF1
    4 View Details [373..540] deduced N/A No confident structure predictions are available.
    5 View Details [541..747] MSA 4.218995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • DNA binding
    		•  5.15324651287773 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.01228762819617 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.9607192917135 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.06355503548774 bayes_pls_golite062009
  • transcription factor activity
    		•  3.82658263870186 bayes_pls_golite062009
  • binding
    		•  3.6211482127468 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.17018042329608 bayes_pls_golite062009
  • transcription activator activity
    		•  2.95665802871704 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.75319687398598 bayes_pls_golite062009
  • protein binding
    		•  2.18211240370246 bayes_pls_golite062009
  • beta-catenin binding
    		•  2.16058631208641 bayes_pls_golite062009
  • chromatin binding
    		•  1.64428658020027 bayes_pls_golite062009
  • transcription factor binding
    		•  1.10315330167937 bayes_pls_golite062009
  • DNA bending activity
    		•  0.87985209274756 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.4255419067266 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.261169200304829 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle