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Protein Overview: rdx-PE

General Information:
Name(s) found: rdx-PE / FBpp0099767 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene roadkill is referred to in FlyBase by the symbol Dmel\rdx (CG12537, FBgn0086364). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:9793674..9857777. It has the cytological map location 88A3-88A4. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: eye development; eye morphogenesis; establishment of ommatidial polarity; regulation of proteolysis; segment polarity determination; positive regulation of JNK cascade; cellularization; positive regulation of apoptosis; protein ubiquitination. 58 alleles are reported. The phenotypes of these alleles are annotated with: retina; interommatidial bristle; wing; ommatidial precursor cluster. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 829 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    Biological Process: eye development [IMP]
    eye morphogenesis [IMP]
    positive regulation of JNK cascade [IMP]
    positive regulation of apoptosis [IGI]
    regulation of proteolysis [IMP]
    establishment of ommatidial planar polarity [IMP]
    segment polarity determination [IMP]
    cellularization [IMP]
    protein ubiquitination [IMP]
    Molecular Function: protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFEPYVKIKK KRSVNEIYEN ENLEQQQHHL QQQQQQPATS DNCCCENGEP QNAPEVATAT  60
   61 VAATSVAATS AAATVATGAA ASSSSSGNCS RLQQLISTPP VLLRRSSLQQ QQHQQQQHHP 120
  121 HTPAATATPP QQQQQQQAAP SVLQQHLGHL NYESGATAAA AATAAAAAAT VATSRSGSAT 180
  181 LAQHLATPSN ILQAAFGSSN LQHILTRSAP SPSSSAISSN NCSSACAGNT HYNGGNSNSG 240
  241 SSSSNSNHHS NSIIASRLFG AASSSSSSSS SSASASSSSV AASSSSSSHH LHSHHSALTN 300
  301 SITNRINQSI RRHLNQQQHH HPLSASSSSA SASPSASTSS SSSYQQSSVQ QQHYNCAHPA 360
  361 QQQQHHHHHH SSSSSSSSSS SSSHHHHNSS SSSNSNNQQQ PQQSPLCLVL LVKCPNSKEF 420
  421 CNAAANFCDK RLPVNECQAS QTARVTSNLH ASSSTMAVSR VPSPPLPEVN TPVAENWCYT 480
  481 QVKVVKFSYM WTINNFSFCR EEMGEVLKSS TFSAGANDKL KWCLRVNPKG LDEESKDYLS 540
  541 LYLLLVSCNK SEVRAKFKFS ILNAKREETK AMESQRAYRF VQGKDWGFKK FIRRDFLLDE 600
  601 ANGLLPEDKL TIFCEVSVVA DSVNISGQSN IVQFKVPECK LSEDLGNLFD NEKFSDVTLS 660
  661 VGGREFQAHK AILAARSDVF AAMFEHEMEE RKLNRVAITD VDHEVLKEML RFIYTGKAPN 720
  721 LEKMADDLLA AADKYALEKL KVMCEEALCV NLSVETAAET LILADLHSAD QLKAQTIDFI 780
  781 NTHATDVMET SGWQNMITTH SHLIAEAFRA LATQQIPPIG PPRKRVKMS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..466] PSI-BLAST 4.045757 No description for 1y0fB was found.
    2 View Details [467..629] PSI-BLAST 45.154902 Solution structure of N-terminal domain of speckle-type POZ protein
    3 View Details [630..752] PSI-BLAST 30.0 No description for 2nn2A was found.
    4 View Details [753..829] PSI-BLAST 8.0 No description for 2eqxA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  3.89053628409867 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  3.68249288112226 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.77614213354896 bayes_pls_golite062009
  • binding
    		•  2.72457822303946 bayes_pls_golite062009
  • protein binding
    		•  1.74340583625887 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.37597575764906 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.31204855886285 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.07240204386411 bayes_pls_golite062009
  • DNA binding
    		•  0.996677220619186 bayes_pls_golite062009
  • catalytic activity
    		•  0.00622013180681097 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.73

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle