Protein Overview: A2MG_RAT

General Information:
Name(s) found:	A2MG_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|71051900\|gb\|AAH98922.1\| Alpha-2-macroglobulin [Rattus norvegicus] [NCBI NR] gi\|158138551\|ref\|NP_036620.2\| alpha-2-macroglobulin [Rattus norvegicus] [NCBI NR] gi\|119370261\|sp\|P06238.2\|A2MG_RAT RecName: Full=Alpha-2-macroglobulin; Short=Alpha-2-M; Flags: Precursor [NCBI NR] Alpha-2-macroglobulin OS=Rattus norvegicus GN=A2m PE=2 SV=2 [Swiss-Prot] Tax_Id=10116 Alpha-2-macroglobulin [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta] Alpha-2-macroglobulin precursor (Alpha-2-M) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] alpha-2-macroglobulin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Alpha-2-macroglobulin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=A2m Alpha-2-macroglobulin [rat-ipi-250309-contam.fasta] Alpha-2-macroglobulin OS=Rattus norvegicus GN=A2m [011711_HMR.fasta] Isoform of P06238, Alpha-2-macroglobulin OS=Rattus norvegicus GN=LOC100911545 PE=1 SV=2 [RAT.fasta.20160308]
Organism:	Rattus norvegicus
Length:	1472 amino acids
Gene Ontology:
Cellular Component:	platelet alpha granule lumen [UNKNOWN] extracellular space [IEA] extracellular region [UNKNOWN][IEA]
Biological Process:	inflammatory response [TAS] response to glucocorticoid stimulus [IEP] negative regulation of complement activation, lectin pathway [UNKNOWN][IEA] response to wounding [TAS] response to chemical stimulus [IEP] response to nutrient [IEP] acute-phase response [IEP] response to carbon dioxide [IEP]
Molecular Function:	peptidase inhibitor activity [TAS] serine-type endopeptidase inhibitor activity [UNKNOWN][IEA] growth factor binding [UNKNOWN] interleukin-8 binding [UNKNOWN][IEA] endopeptidase inhibitor activity [NAS] protein binding [UNKNOWN] tumor necrosis factor binding [UNKNOWN][IEA] receptor binding [TAS] interleukin-1 binding [UNKNOWN][IEA] enzyme binding [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKHRLRSLA LLPLLLRLLL LLLPTDASAP QKPIYMVMVP SLLHAGTPEK ACFLFSHLNE  60
   61 TVAVRVSLES VRGNQSLFTD LVVDKDLFHC TSFTVPQSSS DEVMFFTVQV KGATHEFRRR 120
  121 STVLVKKKES LVFAQTDKPI YKPGQTVRFR VVSLDESFHP LNELIPLLYI QDPKNNRIAQ 180
  181 WQNFNLEGGL KQLSFPLSSE PTQGSYKVVI RTESGRTVEH PFSVEEFVLP KFEVRVTVPE 240
  241 TITILEEEMN VSVCGIYTYG KPVPGRVTVN ICRKYSNPSN CFGEESVAFC EKLSQQLDGR 300
  301 GCFSQLVKTK SFQLKRQEYE MQLDVHAKIQ EEGTGVEETG KGLTKITRTI TKLSFVNVDS 360
  361 HFRQGIPFVG QVLLVDGRGT PIPYETIFIG ADEANLYINT TTDKHGLARF SINTDDIMGT 420
  421 SLTVRAKYKD SNACYGFRWL TEENVEAWHT AYAVFSPSRS FLHLESLPDK LRCDQTLEVQ 480
  481 AHYILNGEAM QELKELVFYY LMMAKGGIVR AGTHVLPLKQ GQMRGHFSIL ISMETDLAPV 540
  541 ARLVLYAILP NGEVVGDTAK YEIENCLANK VDLVFRPNSG LPATRALLSV MASPQSLCGL 600
  601 RAVDQSVLLM KPETELSASL IYDLLPVKDL TGFPQGADQR EEDTNGCVKQ NDTYINGILY 660
  661 SPVQNTNEED MYGFLKDMGL KVFTNSNIRK PKVCERLRDN KGIPAAYHLV SQSHMDAFLE 720
  721 SSESPTETRR SYFPETWIWD LVVVDSAGVA EVEVTVPDTI TEWKAGAFCL SNDTGLGLSP 780
  781 VVQFQAFQPF FVELTMPYSV IRGEAFTLKA TVLNYLPTCI RVAVQLEASP DFLAAPEEKE 840
  841 QRSHCICMNQ RHTASWAVIP KSLGNVNFTV SAEALNSKEL CGNEVPVVPE QGKKDTIIKS 900
  901 LLVEPEGLEN EVTFNSLLCP MGAEVSELIA LKLPSDVVEE SARASVTVLG DILGSAMQNT 960
  961 QDLLKMPYGC GEQNMVLFAP NIYVLDYLNE TQQLTQEIKT KAIAYLNTGY QRQLNYKHRD1020
 1021 GSYSTFGDKP GRNHANTWLT AFVLKSFAQA RKYIFIDEVH ITQALLWLSQ QQKDNGCFRS1080
 1081 SGSLLNNAMK GGVEDEVTLS AYITIALLEM SLPVTHPVVR NALFCLDTAW KSARGGAGGS1140
 1141 HVYTKALLAY AFALAGNQDT KKEILKSLDE EAVKEEDSVH WTRPQKPSVS VALWYQPQAP1200
 1201 SAEVEMTAYV LLAYLTTEPA PTQEDLTAAM LIVKWLTKQQ NSHGGFSSTQ DTVVALHALS1260
 1261 KYGSATFTRA KKAAQVTIHS SGTFSTKFQV NNNNQLLLQR VTLPTVPGDY TVKVTGEGCV1320
 1321 YLQTSLKYSV LPREEEFPFT VVVQTLPGTC EDPKAHTSFQ ISLNISYTGS RSESNMAIAD1380
 1381 VKMVSGFIPL KPTVKMLERS VHVSRTEVSN NHVLIYLDKV SNQTVNLSFT VQQDIPIRDL1440
 1441 KPAVVKVYDY YEKDEFAVAK YSAPCSTDYG NA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: A2MG_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: