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Protein Overview: Hsf-PB

General Information:
Name(s) found: Hsf-PB / FBpp0110264 [FlyBase]
Description(s) found:
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  • gi|71142993|dbj|BAE16321.1| heat shock transcription factor b [Drosophila melanogaster] [NCBI NR]
  • gi|116007718|ref|NP_001036557.1| heat shock factor, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|113194664|gb|ABI31104.1| heat shock factor, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene Heat shock factor is referred to in FlyBase by the symbol Dmel\Hsf (CG5748, FBgn0001222). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:14017808..14022136. It has the cytological map location 55B7-55B8. There is experimental evidence that it has the molecular function</span>: specific RNA polymerase II transcription factor activity; transcription activator activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene-specific transcription from RNA polymerase II promoter; response to heat. 89 alleles are reported. The phenotypes of these alleles are annotated with: polytene chromosome; egg chamber; nurse cell. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • type=protein; loc=2R:complement(14018260..14018411,14018475..14018550,14018787..14019239,14019299..14020446,14020509..14020617,14021376..14021585); ID=FBpp0110264; name=Hsf-PB; parent=FBgn0001222,FBtr0110964; dbxref=FlyBase:FBpp0110264,FlyBase_Annotation_ [fly-100309-contam.fasta]
  • Heat shock factor CG5748-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG5748-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • heat shock transcription factor b [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(14018260..14018411,14018475..14018550,14018787..14019239,14019299..14020446,14020509..14020617,14021376..14021585); ID=FBpp0110264; name=Hsf-PB; parent=FBgn0001222,FBtr0110964; dbxref=FlyBase:FBpp0110264,FlyBase_Annotation_IDs:CG5748-PB,REFSEQ:NP_001036557,GB_protein:ABI31104; MD5=e431afc2c66e10bf5fde8ad4842a4aa7; length=715; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(14018260..14018411,14018475..14018550,14018787..14019239,14019299..14020446,14020509..14020617,14021376..14021585); ID=FBpp0110264; name=Hsf-PB; parent=FBgn0001222,FBtr0110964; dbxref=FlyBase:FBpp0110264,FlyBase_Annotation_IDs:CG5748-PB,REFSEQ:NP_001036557,GB_protein:ABI31104; MD5=e431afc2c66e10bf5fde8ad4842a4aa7; length=715; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Heat shock factor, isoform B OS=Drosophila melanogaster GN=Hsf PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(14018260..14018411,14018475..14018550,14018787..14019239,14019299..14020446,14020509..14020617,14021376..14021585); ID=FBpp0110264; name=Hsf-PB; parent=FBgn0001222,FBtr0110964; dbxref=FlyBase:FBpp0110264,FlyBase_Annotation_IDs:CG5748-PB,REFSEQ:NP_001036557,GB_protein:ABI31104,FlyMine:FBpp0110264,modMine:FBpp0110264; MD5=e431afc2c66e10bf5fde8ad4842a4aa7; length=715; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(18133871..18134080,18133004..18133112,18131794..18132941,18131282..18131734,18130970..18131045,18130755..18130906)); ID=FBpp0110264; name=Hsf-PB; parent=FBgn0001222,FBtr0110964; dbxref=FlyBase:FBpp0110264,FlyBase_Annotation_IDs:CG5748-PB,REFSEQ:NP_001036557,GB_protein:ABI31104,FlyMine:FBpp0110264,modMine:FBpp0110264; MD5=e431afc2c66e10bf5fde8ad4842a4aa7; length=715; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(18133871..18134080,18133004..18133112,18131794..18132941,18131282..18131734,18130970..18131045,18130755..18130906)); ID=FBpp0110264; name=Hsf-PB; parent=FBgn0001222,FBtr0110964; dbxref=FlyBase:FBpp0110264,FlyBase_Annotation_IDs:CG5748-PB,REFSEQ:NP_001036557,GB_protein:ABI31104,FlyMine:FBpp0110264,modMine:FBpp0110264; MD5=e431afc2c66e10bf5fde8ad4842a4aa7; length=715; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of P22813, Heat shock factor, isoform B OS=Drosophila melanogaster GN=Hsf PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0110264 type=protein; loc=2R:complement(join(18133871..18134080,18133004..18133112,18131794..18132941,18131282..18131734,18130970..18131045,18130755..18130906)); ID=FBpp0110264; name=Hsf-PB; parent=FBgn0001222,FBtr0110964; dbxref=FlyBase:FBpp0110264,FlyBase_Annotation_IDs:CG5748-PB,REFSEQ:NP_001036557,GB_protein:ABI31104,FlyMine:FBpp0110264,modMine:FBpp0110264; MD5=e431afc2c66e10bf5fde8ad4842a4aa7; length=715; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(18133871..18134080,18133004..18133112,18131794..18132941,18131282..18131734,18130970..18131045,18130755..18130906)); ID=FBpp0110264; name=Hsf-PB; parent=FBgn0001222,FBtr0110964; dbxref=FlyBase:FBpp0110264,FlyBase_Annotation_IDs:CG5748-PB,REFSEQ:NP_001036557,GB_protein:ABI31104,UniProt/TrEMBL:Q4H2F9,FlyMine:FBpp0110264,modMine:FBpp0110264; MD5=e431afc2c66e10bf5fde8ad4842a4aa7; length=715; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 715 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRSRSSAKA VQFKHESEEE EEDEEEQLPS RRMHSYGDAA AIGSGVPAFL AKLWRLVDDA  60
   61 DTNRLICWTK DGQSFVIQNQ AQFAKELLPL NYKHNNMASF IRQLNMYGFH KITSIDNGGL 120
  121 RFDRDEIEFS HPFFKRNSPF LLDQIKRKIS NNKNGDDKGV LKPEAMSKIL TDVKVMRGRQ 180
  181 DNLDSRFSAM KQENEVLWRE IASLRQKHAK QQQIVNKLIQ FLITIVQPSR NMSGVKRHVQ 240
  241 LMINNTPEID RARTTSETES ESGGGPVIHE LREELLDEVM NPSPAGYTAA SHYDQESVSP 300
  301 PAVERPRSNM SISSHNVDYS NQSVEDLLLQ GNGTAGGNIL VGGAASPMAQ SVSQSPAQHD 360
  361 VYTVTEAPDS HVQEVPNSPP YYEEQNVLTT PMVREQEQQK RQQLKENNKL RRQAGDVILD 420
  421 AGDILVDSSS PKAQRTSIQH STQPDVMVQP MIIKSEPENS SGLMDLMTPA NDLYSVNFIS 480
  481 EDMPTDIFED ALLPDGVEEA AKLDQQQKFG QSTVSSGKFA SNFDVPTNST LLDANQASTS 540
  541 KAAAKAQASE EEGMAVAKYS GAENGNNRDT NNSQLLRMAS VLVDQKNTNS SRISHNQAAN 600
  601 SYCCSDELHG HLESMQDELE TLKDLLRGDG VAIDQNMLMG LFNDSDLMDN YGLSFPNDSI 660
  661 SSEKKAPSGS ELISYQPMYD LSDILDTDDG NNDQEASRRQ MQTQSSVLNT PRHEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..153] PSI-BLAST 38.522879 SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR
    2 View Details [154..248] Pfam 10.102373 No description for PF00447.8 was found. No confident structure predictions are available.
    3 View Details [249..475] deduced N/A No confident structure predictions are available.
    4 View Details [476..608] MSA 5.195997 View MSA. No confident structure predictions are available.
    5 View Details [609..715] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.99681957904233 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription activator activity
    		•  3.70589483230587 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.58179858678904 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.22485867684613 bayes_pls_golite062009
  • protein binding
    		•  1.80415286835431 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.23177057841536 bayes_pls_golite062009
  • structural molecule activity
    		•  0.111941063082739 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.0565989703351002 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle