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View Structure Prediction Details

Protein: Hsf-PB
Organism: Drosophila melanogaster
Length: 715 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Hsf-PB.

Description E-value Query
Range
Subject
Range
Hsf-PD - The gene Heat shock factor is referred to in FlyBase by the symbol Dmel\Hsf (CG5748, FBgn0001222). I...
550.0 [0..1] [715..1]

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Predicted Domain #1
Region A:
Residues: [1-153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRSRSSAKA VQFKHESEEE EEDEEEQLPS RRMHSYGDAA AIGSGVPAFL AKLWRLVDDA  60
   61 DTNRLICWTK DGQSFVIQNQ AQFAKELLPL NYKHNNMASF IRQLNMYGFH KITSIDNGGL 120
  121 RFDRDEIEFS HPFFKRNSPF LLDQIKRKIS NNK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.522879
Match: 1hksA
Description: SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription activator activity 3.70589483230587 bayes_pls_golite062009
sequence-specific DNA binding 3.58179858678904 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009
structural molecule activity 0.111941063082739 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [154-248]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGDDKGVLKP EAMSKILTDV KVMRGRQDNL DSRFSAMKQE NEVLWREIAS LRQKHAKQQQ  60
   61 IVNKLIQFLI TIVQPSRNMS GVKRHVQLMI NNTPE

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 10.102373
Match: PF00447.8
Description: No description for PF00447.8 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [249-475]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDRARTTSET ESESGGGPVI HELREELLDE VMNPSPAGYT AASHYDQESV SPPAVERPRS  60
   61 NMSISSHNVD YSNQSVEDLL LQGNGTAGGN ILVGGAASPM AQSVSQSPAQ HDVYTVTEAP 120
  121 DSHVQEVPNS PPYYEEQNVL TTPMVREQEQ QKRQQLKENN KLRRQAGDVI LDAGDILVDS 180
  181 SSPKAQRTSI QHSTQPDVMV QPMIIKSEPE NSSGLMDLMT PANDLYS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [476-608]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNFISEDMPT DIFEDALLPD GVEEAAKLDQ QQKFGQSTVS SGKFASNFDV PTNSTLLDAN  60
   61 QASTSKAAAK AQASEEEGMA VAKYSGAENG NNRDTNNSQL LRMASVLVDQ KNTNSSRISH 120
  121 NQAANSYCCS DEL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [609-715]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGHLESMQDE LETLKDLLRG DGVAIDQNML MGLFNDSDLM DNYGLSFPND SISSEKKAPS  60
   61 GSELISYQPM YDLSDILDTD DGNNDQEASR RQMQTQSSVL NTPRHEL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle