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Protein Overview: Ih-PB

General Information:
Name(s) found: Ih-PB / FBpp0099777 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene I<down>h</down> channel is referred to in FlyBase by the symbol Dmel\Ih (CG8585, FBgn0028428). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10166938..10186413. It has the cytological map location 50E6-50F1. Based on sequence similarity, it is predicted to have molecular function</span>: intracellular cyclic nucleotide activated cation channel activity; voltage-gated ion channel activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: transmembrane transport; potassium ion transport. 5 alleles are reported. No phenotypic data is available. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1290 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    plasma membrane [ISS]
    Biological Process: potassium ion transport [IEA]
    transmembrane transport [IEA]
    Molecular Function: voltage-gated potassium channel activity [IEA]
    voltage-gated ion channel activity [ISS][NAS]
    intracellular cyclic nucleotide activated cation channel activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHVKHTQRRV SGPGAFGTFT NDQRASRDNL CPDNQQQQQQ RHSHSHQHLV RQSLVSLSNG  60
   61 QPAASAAPDS VSLLRAGDDQ QQHPQQPHLQ QQQQQQQHLQ QQQQRHRSSS SRLSTSGISK 120
  121 QNSSDSRSGL RILDSSHSPV SCGTQSVSST GGQSALYDAC HEYSRSLSAA AAEGAASLLK 180
  181 SHYSDQQLAQ TEPDPEPDPE RDRDRDRDRD RDRERERRHL TNLNLNLSSE YDYSGSDKQQ 240
  241 LVNETYIFKC IANSPSFLRT NKIKEQSKKL RNLSLKTRTA KKKGQIISKS NAVSDNSLHP 300
  301 GDKYLNLYLV EKKHSLQPQV ASTSSSINTT HPQASSAPAS SSSTCTKAPQ LPALSAVAAR 360
  361 QQQLLLNGSL KGKGQSQSQG QSRQTLPGHR ASVRSESGSG SSHTIPATGK SPPVPHSLAA 420
  421 KISSSASGSK NCNLLSASSN SCHKLNAHAQ GSGAGSGSGS GSGSGPPGHS HYAAASPKSS 480
  481 VSSNGHLNKY CLTDLTRRKA EFNRQLSAPT DYTHHSSSNG SQQEGSSEAN EGHEPVGEST 540
  541 ITVASAGVSY PHPYSYPYHY AHHASSATAP ANLKASLQLH SFGSHHPCPY PARPTSTSCT 600
  601 NSFNRRHIRR HKGKLGDRLL SGDSEESVRC SYCSVLNVND NDLRISFENT CTDSLVTAFD 660
  661 DEALLICDQG TEMVHFDDVS LYGTPKEEPM PNIPIVSEKV SANFLKSQLQ SWFQPTDNRL 720
  721 AMKLFGSRKA LVKERIRQKT SGHWVIHPCS SFRFYWDLCM LLLLVANLII LPVAISFFND 780
  781 DLSTRWIAFN CLSDTIFLID IVVNFRTGIM QQDNAEQVIL DPKLIAKHYL RTWFFLDLIS 840
  841 SIPLDYIFLI FNQDFSDSFQ ILHAGRALRI LRLAKLLSLV RLLRLSRLVR YVSQWEEVYF 900
  901 LNMASVFMRI FNLICMMLLI GHWSGCLQFL VPMLQGFPSN SWVSINELQE SYWLEQYSWA 960
  961 LFKAMSHMLC IGYGRFPPQS LTDMWLTMLS MISGATCYAL FLGHATNLIQ SLDSSRRQYR1020
 1021 EKVKQVEEYM AYRKLPRDMR QRITEYFEHR YQGKFFDEEL ILGELSEKLR EDVINYNCRS1080
 1081 LVASVPFFAN ADSNFVSDVV TKLKYEVFQP GDIIIKEGTI GTKMYFIQEG VVDIVMANGE1140
 1141 VATSLSDGSY FGEICLLTNA RRVASVRAET YCNLFSLSVD HFNCVLDQYP LMRKTMETVA1200
 1201 AERLNKIGKN PNIMHQKDEQ LSNPESNTIT AVVNALAAEA DDCKDDDMDL KENLLHGSES1260
 1261 SIAEPVQTIR EGLPRPRSGE FRALFEGNTP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..135] deduced N/A No confident structure predictions are available.
    2 View Details [136..331] deduced N/A No confident structure predictions are available.
    3 View Details [332..428] deduced N/A No confident structure predictions are available.
    4 View Details [429..602] MSA 1.582995 View MSA. No confident structure predictions are available.
    5 View Details [603..713] deduced N/A No confident structure predictions are available.
    6 View Details [714..750] Pfam 33.823909 No description for PF08412.1 was found. No confident structure predictions are available.
    7 View Details [751..1090] PSI-BLAST 17.69897 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    8 View Details [1091..1290] PSI-BLAST 37.221849 HCN2J 443-645 in the presence of cGMP


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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